Doublecortin antibody (C-Term)
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- Target See all Doublecortin (DCX) Antibodies
- Doublecortin (DCX)
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Pig, Horse, Dog
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Doublecortin antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- TAGPKASPTP QKTSAKSPGP MRRSKSPADS ANGTSSSQLS TPKSKQSPIS
- Predicted Reactivity
- Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%
- Characteristics
- This is a rabbit polyclonal antibody against DCX. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human DCX
- Top Product
- Discover our top product DCX Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 441 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Doublecortin (DCX)
- Alternative Name
- DCX (DCX Products)
- Synonyms
- DCX antibody, DBCN antibody, DC antibody, LISX antibody, SCLH antibody, XLIS antibody, Dbct antibody, 18C15.5 antibody, doublecortin antibody, DCX antibody, Dcx antibody
- Background
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In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The protein contains two doublecortin domains, which bind microtubules. In addition, DCX interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex.In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene.
Alias Symbols: DBCN, DC, LISX, SCLH, XLIS
Protein Interaction Partner: KIFC3, GOLGA2, TRIM23, KRTAP10-8, KRT40, RINT1, MID2, SPAG5, IKZF1, CALCOCO2, ZBTB5, TRIM27, MEOX1, FBXO25, APP, PPP1R9B, PPP1CA, PAFAH1B1, ACD, TINF2, POT1, TERF1, SPP1, USP9X, NFASC, TRIM39, AP1M1, AP2M1, DCX, CDK5,
Protein Size: 441 - Molecular Weight
- 49 kDa
- Gene ID
- 1641
- NCBI Accession
- NM_000555, NP_000546
- UniProt
- O43602
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