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TPM3 antibody (Middle Region)

TPM3 Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2776646
  • Target See all TPM3 Antibodies
    TPM3 (Tropomyosin 3 (TPM3))
    Binding Specificity
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 27
    • 16
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)
    Host
    • 25
    • 5
    Rabbit
    Clonality
    • 26
    • 4
    Polyclonal
    Conjugate
    • 19
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TPM3 antibody is un-conjugated
    Application
    • 18
    • 10
    • 10
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    TEERAELAES RCREMDEQIR LMDQNLKCLS AAEEKYSQKE DKYEEEIKIL
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against TPM3. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human TPM3
    Top Product
    Discover our top product TPM3 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 285 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Ramsey, Clarke, Roberts, Sullivan, Johnson, Liu: "An economic evaluation of atorvastatin for primary prevention of cardiovascular events in type 2 diabetes." in: PharmacoEconomics, Vol. 26, Issue 4, pp. 329-39, (2008) (PubMed).

  • Target
    TPM3 (Tropomyosin 3 (TPM3))
    Alternative Name
    TPM3 (TPM3 Products)
    Synonyms
    CAPM1 antibody, CFTD antibody, NEM1 antibody, OK/SW-cl.5 antibody, TM-5 antibody, TM3 antibody, TM30 antibody, TM30nm antibody, TM5 antibody, TPMsk3 antibody, TRK antibody, hscp30 antibody, cb674 antibody, fa17b11 antibody, fb83b01 antibody, fk41e01 antibody, hm:zeh0298 antibody, wu:fa17b11 antibody, wu:fb83b01 antibody, wu:fk41e01 antibody, zeh0298 antibody, zgc:77592 antibody, TPM3 antibody, Tm5NM antibody, Tpm-5 antibody, Tpm5 antibody, Trop-5 antibody, gamma-TM antibody, hTM30nm antibody, hTMnm antibody, tm3 antibody, tpm3 antibody, tpm3.L antibody, tropomyosin 3 antibody, tropomyosin 3, gamma antibody, tropomyosin 3 S homeolog antibody, TPM3 antibody, tpm3 antibody, Tpm3 antibody, tpm3.S antibody
    Background
    TPM3 is a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer.This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
    Alias Symbols: FLJ41118, MGC14582, MGC3261, MGC72094, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TPMsk3, TRK, hscp30, TM5, CFTD, hTM5
    Protein Interaction Partner: TLK1, MAD1L1, TRIP6, TPM3, TP53, TNNT1, VPS52, TRIM27, PBX3, MAGEA11, KIFC3, KCNE1, IFIT3, HSF2, LURAP1, WASH3P, HDDC3, FAM9C, LCA5L, C1orf216, IKBIP, SYCE1, CCDC114, CCDC102B, KXD1, CCDC146, THAP1, CCHCR1, TFPT, BLOC1S6, OIP5, UBC, MDM2, RNF2, MAGED2, MG
    Protein Size: 285
    Molecular Weight
    33 kDa
    Gene ID
    7170
    NCBI Accession
    NM_153649, NP_705935
    UniProt
    P06753
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