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EXOSC6 antibody (N-Term)

EXOSC6 Reactivity: Human, Mouse, Rat, Cow, Pig, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2776613
  • Target See all EXOSC6 Antibodies
    EXOSC6 (Exosome Component 6 (EXOSC6))
    Binding Specificity
    • 14
    • 12
    N-Term
    Reactivity
    • 21
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Cow, Pig, Zebrafish (Danio rerio)
    Host
    • 21
    Rabbit
    Clonality
    • 21
    Polyclonal
    Conjugate
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    This EXOSC6 antibody is un-conjugated
    Application
    • 20
    • 14
    • 3
    • 1
    Western Blotting (WB)
    Sequence
    LYAADEEEAP GTRDPTRLRP VYARAGLLSQ AKGSAYLEAG GTKVLCAVSG
    Predicted Reactivity
    Cow: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against EXOSC6. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human EXOSC6
    Top Product
    Discover our top product EXOSC6 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 272 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    EXOSC6 (Exosome Component 6 (EXOSC6))
    Alternative Name
    EXOSC6 (EXOSC6 Products)
    Synonyms
    exosc6 antibody, RAR-gamma antibody, id:ibd1130 antibody, wu:fe17d05 antibody, zgc:110071 antibody, EAP4 antibody, MTR3 antibody, Mtr3p antibody, hMtr3p antibody, p11 antibody, 2610510N21Rik antibody, C76919 antibody, Mtr3 antibody, exosome component 6 antibody, EXOSC6 antibody, exosc6 antibody, CpipJ_CPIJ018071 antibody, Exosc6 antibody
    Background
    EXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.
    Alias Symbols: p11, EAP4, MTR3, Mtr3p, hMtr3p
    Protein Interaction Partner: CEP250, DCP1B, EXOSC6, CHPF, MIF4GD, XRN1, NDUFA13, MRPL4, EXOSC1, MRPS18B, UPF2, RAB3GAP2, SKIV2L2, GSE1, EXOSC7, EXOSC8, ZFP36, TUFM, EXOSC10, MAN2C1, ESRRA, C1QBP, AICDA, DIS3L, EXOSC4, EXOSC3, CUL3, ELAVL1, HDGF, UBC, EXOSC5, DNAJC30, MOCS3, MPP6, EXO
    Protein Size: 272
    Molecular Weight
    30 kDa
    Gene ID
    118460
    NCBI Accession
    NM_058219, NP_478126
    UniProt
    Q5RKV6
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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