FIP1L1 antibody (C-Term)

Catalog No. ABIN2776582

Product Details anti-FIP1L1 Antibody

Target: FIP1L1 (FIP1 Like 1 (FIP1L1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig, Zebrafish (Danio rerio), Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FIP1L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: EYAERGYERH RASREKEERH RERRHREKEE TRHKSSRSNS RRRHESEEGD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against FIP1L1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FIP1L1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 594 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FIP1L1

Target: FIP1L1 (FIP1 Like 1 (FIP1L1))

Alternative Name: FIP1L1 (FIP1L1 Products)

Synonyms: FIP1 antibody, Rhe antibody, hFip1 antibody, 1300019H17Rik antibody, Rje antibody, fip1l1 antibody, wu:fd36f11 antibody, zgc:103421 antibody, factor interacting with PAPOLA and CPSF1 antibody, factor interacting with PAPOLA and CPSF1 S homeolog antibody, FIP1 like 1 (S. cerevisiae) antibody, FIP1 like 1b (S. cerevisiae) antibody, fip1l1 antibody, FIP1L1 antibody, fip1l1.S antibody, Fip1l1 antibody, fip1l1b antibody

Background: FIP1L1 is a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. It binds to U-rich RNA sequence elements surrounding the poly(A) site. FIP1L1 may act to tether poly(A) polymerase to the CPSF complex.
Alias Symbols: DKFZp586K0717, FLJ33619, Rhe, hFip1
Protein Interaction Partner: ZMYND19, CPSF4, NAA10, SGTA, GOLGA2, STAU1, UBC, WWOX, SUZ12, RNF2, EZH2, PRMT6, PRMT2, CLK2, HDAC9, CSNK2A1, LIG4, WDR33, CPSF2, CPSF3, CPSF1, NUP153, APP, COPS5, HNRNPA1, SRRM2, RNPS1,
Protein Size: 594

Molecular Weight: 65 kDa

Gene ID: 81608

NCBI Accession: NM_030917, NP_112179

UniProt: Q6UN15