Nucleolar Protein 6 antibody (N-Term)

Catalog No. ABIN2776561

Product Details anti-Nucleolar Protein 6 Antibody

Target: Nucleolar Protein 6 (NOL6)

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nucleolar Protein 6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SRKRTLAEPP AKGLLQPVKL SRAELYKEPT NEELNRLRET EILFHSSLLR

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Yeast: 90%

Characteristics: This is a rabbit polyclonal antibody against NOL6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NOL6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1146 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Nucleolar Protein 6

Target: Nucleolar Protein 6 (NOL6)

Alternative Name: NOL6 (NOL6 Products)

Synonyms: NRAP antibody, UTP22 antibody, bA311H10.1 antibody, nrap antibody, utp22 antibody, AA410091 antibody, Nrap antibody, nucleolar protein 6 antibody, nucleolar protein 6 L homeolog antibody, nucleolar protein family 6 (RNA-associated) antibody, NOL6 antibody, Nol6 antibody, nol6.L antibody

Background: NOL6 is a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified.
Alias Symbols: FLJ21959, MGC14896, MGC14921, MGC20838, NRAP, UTP22, bA311H10.1
Protein Interaction Partner: UBC, SIAH1, LIN28A, RNF2, BMI1, EED, SIRT7, SUMO2, SUMO1, G3BP1,
Protein Size: 1146

Molecular Weight: 127 kDa

Gene ID: 65083

NCBI Accession: NM_022917, NP_075068

UniProt: Q9H6R4