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ZIC2 antibody (C-Term)

ZIC2 Reactivity: Human, Rat, Mouse, Guinea Pig WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2776475
  • Target See all ZIC2 Antibodies
    ZIC2
    Binding Specificity
    • 15
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 18
    • 15
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Guinea Pig
    Host
    • 31
    • 2
    • 1
    Rabbit
    Clonality
    • 32
    • 2
    Polyclonal
    Conjugate
    • 11
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ZIC2 antibody is un-conjugated
    Application
    • 23
    • 13
    • 13
    • 8
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    EPQSSSNLSP AAAAAAAAAA AAAAAVSAVH RGGGSGSGGA GGGSGGGSGS
    Predicted Reactivity
    Guinea Pig: 87%, Human: 100%, Mouse: 85%, Rat: 92%
    Characteristics
    This is a rabbit polyclonal antibody against ZIC2. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human ZIC2
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 532 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Toth, Schiffmann, Hube-Magg, Büscheck, Höflmayer, Weidemann, Lebok, Fraune, Minner, Schlomm, Sauter, Plass, Assenov, Simon, Meiners, Gerhäuser: "Random forest-based modelling to detect biomarkers for prostate cancer progression." in: Clinical epigenetics, Vol. 11, Issue 1, pp. 148, (2020) (PubMed).

    Inaguma, Ito, Riku, Ikeda, Kasai: "Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2." in: Oncotarget, Vol. 6, Issue 29, pp. 28257-68, (2015) (PubMed).

    Zhu, Wang, He, Huang, Du, Zhang, Yan, Xia, Ye, Wang, Hao, Wu, Fan: "ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells." in: The Journal of clinical investigation, Vol. 125, Issue 10, pp. 3795-808, (2015) (PubMed).

    McCampbell, Truong, Broom, Allchorne, Gable, Cutler, Mattson, Woolf, Frosch, Harmon, Dunn, Brown: "Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy." in: Human molecular genetics, Vol. 14, Issue 22, pp. 3507-21, (2005) (PubMed).

  • Target
    ZIC2
    Alternative Name
    ZIC2 (ZIC2 Products)
    Synonyms
    HPE5 antibody, Ku antibody, cb851 antibody, fb26a03 antibody, wu:fb26a03 antibody, zic2 antibody, zic2.1 antibody, hpe5 antibody, hm:zeh0655 antibody, id:ibd5017 antibody, zic2.2 antibody, zic2l antibody, Zic family member 2 antibody, zinc finger protein of the cerebellum 2 antibody, zic family member 2 (odd-paired homolog, Drosophila), a antibody, Zic family member 2 L homeolog antibody, zic family member 2 (odd-paired homolog, Drosophila) b antibody, ZIC2 antibody, Zic2 antibody, zic2a antibody, zic2.L antibody, zic2b antibody
    Background
    ZIC2 is a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects.This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
    Alias Symbols: HPE5
    Protein Interaction Partner: SUMO1, ELAVL1, GLI3, GLI2, GLI1, RNF180, UBC,
    Protein Size: 532
    Molecular Weight
    55 kDa
    Gene ID
    7546
    NCBI Accession
    NM_007129, NP_009060
    UniProt
    O95409
    Pathways
    Tube Formation
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