TCEAL1 antibody (Middle Region)

Catalog No. ABIN2776430

Product Details anti-TCEAL1 Antibody

Target: TCEAL1 (Transcription Elongation Factor A (SII)-Like 1 (TCEAL1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCEAL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: EGLSRKDLFE GRPPMEQPPC GVGKHKLEEG SFKERLARSR PQFRGDIHGR

Predicted Reactivity: Cow: 87%, Dog: 87%, Horse: 87%, Human: 87%, Mouse: 87%, Pig: 87%, Rabbit: 87%, Rat: 80%

Characteristics: This is a rabbit polyclonal antibody against TCEAL1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TCEAL1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 159 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TCEAL1 antibody (ABIN2776430)

Klos, Wyszomierski, Sun, Tan, Zhou, Li, Yang, Yin, Hittelman, Yu: "ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells." in: Cancer research, Vol. 66, Issue 4, pp. 2028-37, (2006) (PubMed).

Target Details for TCEAL1

Target: TCEAL1 (Transcription Elongation Factor A (SII)-Like 1 (TCEAL1))

Alternative Name: TCEAL1 (TCEAL1 Products)

Synonyms: SIIR antibody, p21 antibody, pp21 antibody, 0610011M09Rik antibody, BC011290 antibody, P21 antibody, transcription elongation factor A like 1 antibody, transcription elongation factor A (SII)-like 1 antibody, TCEAL1 antibody, Tceal1 antibody

Background: TCEAL1 is a member of the transcription elongation factor A (SII)-like (TCEAL) protein family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. TCEAL1 is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.
Alias Symbols: SIIR, p21, pp21
Protein Interaction Partner: MAPK14, DYRK1B, UBC, HOXB6, USP11, TCEAL2, TCEAL4, FEM1C, PPP2R2D, KDM3A, FEM1A, TIPIN, PDCD5, GMPS, CUL2, USP7, TCEB1, RFC1, HSPA4L, SSR3, PPP2R2A,
Protein Size: 159

Molecular Weight: 19 kDa

Gene ID: 9338

NCBI Accession: NM_001006640, NP_001006641

UniProt: Q15170