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PITX2 antibody (N-Term)

PITX2 Reactivity: Human, Rat, Mouse, Pig, Rabbit, Cow, Dog WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2776373
  • Target See all PITX2 Antibodies
    PITX2 (Paired-Like Homeodomain 2 (PITX2))
    Binding Specificity
    • 10
    • 9
    • 8
    • 8
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 58
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Pig, Rabbit, Cow, Dog
    Host
    • 52
    • 5
    • 1
    Rabbit
    Clonality
    • 55
    • 3
    Polyclonal
    Conjugate
    • 28
    • 6
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PITX2 antibody is un-conjugated
    Application
    • 46
    • 38
    • 6
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    SAVSSSSCHH PQPLAMASVL APGQPRSLDS SKHRLEVHTI SDTSSPEAAE
    Predicted Reactivity
    Cow: 100%, Dog: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against PITX2. It was validated on Western Blot and immunohistochemistry.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human PITX2
    Top Product
    Discover our top product PITX2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 324 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Hatou, Yoshida, Higa, Miyashita, Inagaki, Okano, Tsubota, Shimmura: "Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/?-catenin signaling." in: Stem cells and development, Vol. 22, Issue 5, pp. 828-39, (2013) (PubMed).

  • Target
    PITX2 (Paired-Like Homeodomain 2 (PITX2))
    Alternative Name
    PITX2 (PITX2 Products)
    Synonyms
    ARP1 antibody, Brx1 antibody, IDG2 antibody, IGDS antibody, IGDS2 antibody, IHG2 antibody, IRID2 antibody, Otlx2 antibody, PTX2 antibody, RGS antibody, RIEG antibody, RIEG1 antibody, RS antibody, 9430085M16Rik antibody, Brx1a antibody, Brx1b antibody, Munc30 antibody, Pitx2a antibody, Pitx2b antibody, Pitx2c antibody, Pitx2cbeta antibody, Ptx2 antibody, Rieg antibody, pitx2a antibody, pitx2c antibody, zgc:110508 antibody, XPtx2b antibody, xPtx2 antibody, xpitx2 antibody, arp1 antibody, brx1 antibody, idg2 antibody, igds antibody, igds2 antibody, ihg2 antibody, irid2 antibody, otlx2 antibody, pitx2-A antibody, ptx2 antibody, rgs antibody, rieg antibody, rieg1 antibody, pitx-2 antibody, pitx2 antibody, paired like homeodomain 2 antibody, paired-like homeodomain transcription factor 2 antibody, paired-like homeodomain 2 antibody, paired like homeodomain 2 S homeolog antibody, paired like homeodomain 2 L homeolog antibody, PITX2 antibody, Pitx2 antibody, pitx2 antibody, pitx2.S antibody, pitx2.L antibody
    Background
    The PITX2 gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS), and sporadic cases of Peters anomaly. This protein is involved in the development of the eye, tooth and abdominal organs. It also acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.
    Alias Symbols: RS, RGS, ARP1, Brx1, IDG2, IGDS, IHG2, PTX2, RIEG, IGDS2, IRID2, Otlx2, RIEG1
    Protein Interaction Partner: LEF1, Hoxa1, WDR5, SMAD3, HDAC1, CTNNB1, ZNHIT3, TRIM25, HERC5, PDLIM1, PITX2, PROP1, KAT5, Pou1f1, MSX2,
    Protein Size: 324
    Molecular Weight
    36 kDa
    Gene ID
    5308
    NCBI Accession
    NM_000325, NP_000316
    Pathways
    Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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