CATSPER2 antibody (N-Term)

Catalog No. ABIN2776300

Product Details anti-CATSPER2 Antibody

Target: CATSPER2 (Cation Channel, Sperm Associated 2 (CATSPER2))

Binding Specificity: N-Term

Reactivity: Human, Rabbit, Cow, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CATSPER2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: HLQGLSQAVP RHTIRELLDP SRQKKLVLGD QHQLVRFSIK PQRIEQISHA

Predicted Reactivity: Cow: 85%, Horse: 92%, Human: 100%, Pig: 92%, Rabbit: 100%

Characteristics: This is a rabbit polyclonal antibody against CATSPER2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CATSPER2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 414 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CATSPER2 antibody (ABIN2776300)

Kawano, Araki, Yoshida, Hibino, Ohnami, Makino, Kanai, Hasuwa, Yoshida, Miyado, Umezawa: "Seminal vesicle protein SVS2 is required for sperm survival in the uterus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 11, pp. 4145-50, (2014) (PubMed).

Target Details for CATSPER2

Target: CATSPER2 (Cation Channel, Sperm Associated 2 (CATSPER2))

Alternative Name: CATSPER2 (CATSPER2 Products)

Synonyms: CATSPER2 antibody, cation channel, sperm associated 2 antibody, cation channel sperm associated 2 antibody, CATSPER2 antibody, Catsper2 antibody

Background: Calcium ions play a primary role in the regulation of sperm motility. Anti-CATSPER2 belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. A second, closely linked copy of this gene has been identified. Although multiple transcript variants encoding protein isoforms have been characterized, they seem to be only transcribed from this gene. Additional splice variants have been described but their full-length nature has not been determined.
Protein Size: 414

Molecular Weight: 46 kDa

Gene ID: 117155

NCBI Accession: NM_172096, NP_742094

UniProt: Q96P54