CLCNKA antibody (N-Term)

Catalog No. ABIN2776159

Product Details anti-CLCNKA Antibody

Target: CLCNKA (Chloride Channel Ka (CLCNKA))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLCNKA antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MEELVGLREG FSGDPVTLQE LWGPCPHIRR AIQGGLEWLK QKVFRLGEDW

Predicted Reactivity: Cow: 90%, Human: 100%, Mouse: 85%, Pig: 85%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against CLCNKA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CLCNKA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 687 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CLCNKA

Target: CLCNKA (Chloride Channel Ka (CLCNKA))

Alternative Name: CLCNKA (CLCNKA Products)

Background: CLCNKA is a member of the CLC family of voltage-gated chloride channels. It is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CLCK1, ClC-K1, MGC61490, hClC-Ka
Protein Size: 687

Molecular Weight: 75 kDa

Gene ID: 1187

NCBI Accession: NM_004070, NP_004061

UniProt: P51800

Pathways: Response to Water Deprivation