TRIOBP antibody (Middle Region)

Catalog No. ABIN2775973

Product Details anti-TRIOBP Antibody

Target: TRIOBP (TRIO and F-Actin Binding Protein (TRIOBP))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Horse, Guinea Pig, Rabbit, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIOBP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: QIHTKDAVYT LSAMTSGIRR NWIEALRKTV RPTSAPDVTK LSDSNKENAL

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against TRIOBP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TRIOBP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 431 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRIOBP

Target: TRIOBP (TRIO and F-Actin Binding Protein (TRIOBP))

Alternative Name: TRIOBP (TRIOBP Products)

Synonyms: tara antibody, DFNB28 antibody, TARA antibody, dJ37E16.4 antibody, AI428493 antibody, EST478828 antibody, Tara antibody, mKIAA1662 antibody, TRIO and F-actin binding protein antibody, TRIO and F-actin-binding protein antibody, TRIO and F-actin binding protein L homeolog antibody, TRIO and F-actin binding protein-like antibody, TRIOBP antibody, LOC100354753 antibody, triobp.L antibody, TRIOBPL antibody, Triobp antibody

Background: TRIOBP is a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness.This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. This trio-binding protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD).
Alias Symbols: DFNB28, FLJ39315, HRIHFB2122, KIAA1662, TARA, dJ37E16.4
Protein Interaction Partner: POLR1C, IKBKG, GTF2H1, PLK1, ELAVL1, VIM, HECTD3, UBC,
Protein Size: 431

Molecular Weight: 47 kDa

Gene ID: 11078

NCBI Accession: NM_138632, NP_619538

UniProt: Q9H2D6

Pathways: Regulation of Actin Filament Polymerization