TRIM24 antibody (Middle Region)

Catalog No. ABIN2775799

Product Details anti-TRIM24 Antibody

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Cow, Rat, Horse, Dog, Guinea Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM24 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QQPSISHQQP PPRLINFQNH SPKPNGPVLP PHPQQLRYPP NQNIPRQAIK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 82%

Characteristics: This is a rabbit polyclonal antibody against TRIM24. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TRIM24

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1050 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRIM24

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Alternative Name: TRIM24 (TRIM24 Products)

Background: The exact function of TRIM24 remains unknown. The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA, hTIF1
Protein Interaction Partner: UBC, SUMO2, SUMO3, TRIM33, TP53, SUMO1, RNF2, RNF181, RNF141, ESR2, BRCA1, SF3B1, SF3B2, SNRPA, NONO, CDK12, NCOA1, TRIM8, NR3C2, ESR1, HIST1H3E, HIST2H4B, HIST4H4, HIST1H3F, HIST2H4A, HIST1H4L, HIST1H4E, HIST1H4B, HIST1H4H, HIST1H4C, HIST1H4J, HIST1H4K,
Protein Size: 1050

Molecular Weight: 117 kDa

Gene ID: 8805

NCBI Accession: NM_015905, NP_056989

UniProt: O15164