RNF2 antibody (Middle Region)

Catalog No. ABIN2775704

Product Details anti-RNF2 Antibody

Target: RNF2 (Ring Finger Protein 2 (RNF2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Zebrafish (Danio rerio), Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NASTHSNQEA GPSNKRTKTS DDSGLELDNN NAAMAIDPVM DGASEIELVF

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against RNF2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RNF2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 336 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RNF2

Target: RNF2 (Ring Finger Protein 2 (RNF2))

Alternative Name: RNF2 (RNF2 Products)

Synonyms: BAP-1 antibody, BAP1 antibody, DING antibody, HIPI3 antibody, RING1B antibody, RING2 antibody, AI326319 antibody, AI450156 antibody, AU019207 antibody, Ring1B antibody, dinG antibody, fa19h05 antibody, ring1b antibody, wu:fa19h05 antibody, wz4556 antibody, bap-1 antibody, bap1 antibody, ding antibody, hipi3 antibody, ring2 antibody, ring finger protein 2 antibody, ring finger protein 2 L homeolog antibody, RNF2 antibody, Rnf2 antibody, rnf2 antibody, rnf2.L antibody

Background: Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by RNF2 is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.
Alias Symbols: BAP1, DING, BAP-1, HIPI3, RING2, RING1B
Protein Interaction Partner: BMI1, SCMH1, HIST2H2AC, UBE2D3, AMBRA1, WASH1, BECN1, ATG14, PIK3C3, TARDBP, SNAI1, NEDD8, UBC, EIF3I, ALYREF, RBM5, RCL1, TRIM28, CEBPZ, SUGP2, G3BP1, AKAP9, YAF2, LRPPRC, KIF20A, RAD50, ARPC4, ABCB6, SMC4, ACOT8, HNRNPDL, THOC1, THRAP3, RBM8A, KIAA0020,
Protein Size: 336

Molecular Weight: 38 kDa

Gene ID: 6045

NCBI Accession: NM_007212, NP_009143

UniProt: Q99496