CDC23 antibody (C-Term)

Catalog No. ABIN2775691

Product Details anti-CDC23 Antibody

Target: CDC23 (Cell Division Cycle 23 (CDC23))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDC23 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DTREEGKALL RQILQLRNQG ETPTTEVPAP FFLPASLSAN NTPTRRVSPL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CDC23. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CDC23

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 591 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CDC23

Target: CDC23 (Cell Division Cycle 23 (CDC23))

Alternative Name: CDC23 (CDC23 Products)

Synonyms: CDC23 antibody, anaphase-promoting complex subunit 8 antibody, zgc:56013 antibody, 6030435O18 antibody, D18Ertd243e antibody, ANAPC8 antibody, APC8 antibody, CUT23 antibody, cell division cycle 23 antibody, cell division cycle protein 23 homolog antibody, anaphase-promoting complex subunit 8 antibody, CDC23 (cell division cycle 23, yeast, homolog) antibody, cell division cycle 23 S homeolog antibody, CDC23 cell division cycle 23 antibody, CDC23 antibody, LOC100162672 antibody, LOC100380698 antibody, APC8 antibody, cdc23 antibody, cdc23.S antibody, Cdc23 antibody

Background: CDC23 shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.
Alias Symbols: APC8, CUT23, ANAPC8
Protein Interaction Partner: CCDC36, DLX6-AS1, SPERT, KCTD6, FAM9B, CCDC24, SSX2IP, PNMA5, CRACR2A, LZTS2, ATRIP, INCA1, CEP44, SLC52A2, EIF5A2, BCAS3, CYB5R2, HEMK1, RSL24D1, RBM15B, ANAPC2, UBE2S, INPP5J, GORASP2, ANAPC13, RAD54B, RBPMS, OPTN, CDC23, APOL1, COIL, UBC, SOX5, SIAH1,
Protein Size: 591

Molecular Weight: 65 kDa

Gene ID: 8697

NCBI Accession: NM_004661, NP_004652

UniProt: Q9UJX2

Pathways: Protein targeting to Nucleus