AMFR antibody (C-Term)

Catalog No. ABIN2775669

Product Details anti-AMFR Antibody

Target: AMFR (Autocrine Motility Factor Receptor (AMFR))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AMFR antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FGEVEVEPSE VEDFEARGSR FSKSADERQR MLVQRKDELL QQARKRFLNK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against AMFR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human AMFR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 482 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AMFR

Target: AMFR (Autocrine Motility Factor Receptor (AMFR))

Alternative Name: AMFR (AMFR Products)

Synonyms: GP78 antibody, RNF45 antibody, gp78 antibody, wu:fi06e06 antibody, wu:fi37e05 antibody, zgc:63893 antibody, rnf45 antibody, autocrine motility factor receptor antibody, autocrine motility factor receptor L homeolog antibody, autocrine motility factor receptor a antibody, autocrine motility factor receptor, amfr antibody, putative autocrine motility factor receptor, amfr antibody, AMFR antibody, Amfr antibody, amfr.L antibody, amfra antibody, amfr antibody, AaeL_AAEL005881 antibody, CpipJ_CPIJ016043 antibody, Smp_047420 antibody

Background: Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. AMFR is a glycosylated transmembrane protein and a receptor for autocrine motility factor. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells.The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the MKRN1 gene is the ancestral founder of this gene family (Gray et al., 2000).[supplied by OMIM].
Alias Symbols: GP78, RNF45
Protein Interaction Partner: VCP, UBE2G1, HSPA5, ERLIN2, INSIG1, HMGCR, DHFR, AMFR, UBE2D1, UBC, GPI, TRIM25, DGAT2, UBE2K, Ube2g2, NPLOC4, HERPUD1, BAG6, MAVS, YOD1, ADRA1D, DERL2, ADRB2, FAF2, SEC61B, RPN1, STT3A, STT3B, AUP1, MDC1, SNED1, DDOST, GET4, UBXN4, UBL4A, CD82, SARAF, IT
Protein Size: 643

Molecular Weight: 73 kDa

Gene ID: 267

NCBI Accession: NM_013446

UniProt: Q9UKV5

Pathways: ER-Nucleus Signaling