Symplekin antibody (Middle Region)

Catalog No. ABIN2775624

Product Details anti-Symplekin Antibody

Target: Symplekin (SYMPK)

Binding Specificity: Middle Region

Reactivity: Human, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Symplekin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GPLPKETAAG GLTLKEERSP QTLAPVGEDA MKTPSPAAED AREPEAKGNS

Predicted Reactivity: Human: 100%, Pig: 79%, Rat: 82%

Characteristics: This is a rabbit polyclonal antibody against SYMPK. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SYMPK

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1274 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Symplekin

Target: Symplekin (SYMPK)

Alternative Name: SYMPK (SYMPK Products)

Background: SYMPK is a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ27092, SPK, SYM
Protein Interaction Partner: KAT6A, VCP, KMT2A, UBC, WWOX, RPA3, RPA2, RPA1, SSU72, CPSF2, CPSF3, TOP1, SUMO1, SIRT7, SUMO2, SMARCAD1, CSTF2, HTT, HSF1,
Protein Size: 1274

Molecular Weight: 141 kDa

Gene ID: 8189

NCBI Accession: NM_004819, NP_004810

UniProt: Q92797