Pannexin 2 antibody (N-Term)

Catalog No. ABIN2775571

Product Details anti-Pannexin 2 Antibody

Target: Pannexin 2 (PANX2)

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Pannexin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: GTVLVPILLV TLVFTKNFAE EPIYCYTPHN FTRDQALYAR GYCWTELRDA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PANX2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PANX2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 633 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Pannexin 2 antibody (ABIN2775571)

Wicki-Stordeur, Boyce, Swayne: "Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization." in: Cell communication & adhesion, Vol. 20, Issue 3-4, pp. 73-9, (2013) (PubMed).

Mylvaganam, Zhang, Wu, Zhang, Samoilova, Eubanks, Carlen, Poulter: "Hippocampal seizures alter the expression of the pannexin and connexin transcriptome." in: Journal of neurochemistry, Vol. 112, Issue 1, pp. 92-102, (2010) (PubMed).

Swayne, Sorbara, Bennett: "Pannexin 2 is expressed by postnatal hippocampal neural progenitors and modulates neuronal commitment." in: The Journal of biological chemistry, Vol. 285, Issue 32, pp. 24977-86, (2010) (PubMed).

Lai, Bechberger, Naus: "Pannexin2 as a novel growth regulator in C6 glioma cells." in: Oncogene, Vol. 28, Issue 49, pp. 4402-8, (2009) (PubMed).

Wang, Streeter, Liu, Zhao: "Identification and characterization of pannexin expression in the mammalian cochlea." in: The Journal of comparative neurology, Vol. 512, Issue 3, pp. 336-46, (2008) (PubMed).

Target Details for Pannexin 2

Target: Pannexin 2 (PANX2)

Alternative Name: PANX2 (PANX2 Products)

Synonyms: PANX2 antibody, si:ch211-192n14.2 antibody, PX2 antibody, hPANX2 antibody, pannexin 2 antibody, PANX2 antibody, LOC100533356 antibody, panx2 antibody, Panx2 antibody

Background: PANX2 belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties.The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties.
Alias Symbols: hPANX2, PX2
Protein Size: 633

Molecular Weight: 70 kDa

Gene ID: 56666

NCBI Accession: NM_052839, NP_443071

UniProt: Q96RD6