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EIF2AK1 antibody (N-Term)

EIF2AK1 Reactivity: Human, Mouse, Rat, Rabbit, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2775397
  • Target See all EIF2AK1 Antibodies
    EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))
    Binding Specificity
    • 7
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 53
    • 26
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Rabbit, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse
    Host
    • 53
    Rabbit
    Clonality
    • 53
    Polyclonal
    Conjugate
    • 25
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This EIF2AK1 antibody is un-conjugated
    Application
    • 32
    • 27
    • 22
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    TCSDEFSSLR LHHNRAITHL MRSAKERVRQ DPCEDISRIQ KIRSREVALE
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%
    Characteristics
    This is a rabbit polyclonal antibody against EIF2AK1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human EIF2AK1
    Top Product
    Discover our top product EIF2AK1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 630 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))
    Alternative Name
    EIF2AK1 (EIF2AK1 Products)
    Synonyms
    HCR antibody, Hri antibody, HRI antibody, wu:fj97h09 antibody, zgc:153232 antibody, eukaryotic translation initiation factor 2 alpha kinase 1 antibody, eukaryotic translation initiation factor 2-alpha kinase 1 antibody, eukaryotic translation initiation factor 2 alpha kinase 1 L homeolog antibody, EIF2AK1 antibody, eif2ak1 antibody, Eif2ak1 antibody, eif2ak1.L antibody
    Background
    EIF2AK1 acts at the level of translation initiation to downregulate protein synthesis in response to stress. The protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene.The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme. Sequence Note: The sequence AF181071.1 is a chimeric mRNA clone. Only the heme-regulated initiation factor 2-alpha kinase region was propagated into this RefSeq record.
    Alias Symbols: HRI, KIAA1369, HCR
    Protein Interaction Partner: MDM2, UBC, HSP90AA1, LIG4, CDC37, EIF2AK1, EIF2S1,
    Protein Size: 630
    Molecular Weight
    71 kDa
    Gene ID
    27102
    NCBI Accession
    NM_014413, NP_055228
    UniProt
    Q9BQI3
    Pathways
    Hepatitis C
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