PPP2R3B antibody (C-Term)

Catalog No. ABIN2775379

Product Details anti-PPP2R3B Antibody

Target: PPP2R3B (Protein Phosphatase 2A 48 KDa Regulatory Subunit (PPP2R3B))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Dog, Cow, Rat, Zebrafish (Danio rerio), Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP2R3B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TFFNIEKYLD HEQKEQISLL RDGDSGGPEL SDWEKYAAEE YDILVAEETA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 77%, Horse: 77%, Human: 100%, Mouse: 77%, Rabbit: 77%, Rat: 82%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against PPP2R3B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PPP2R3B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 575 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PPP2R3B antibody (ABIN2775379)

van Kempen, Redpath, Elchebly, Klein, Papadakis, Wilmott, Scolyer, Edqvist, Pontén, Schadendorf, van Rijk, Michiels, Dumay, Helbling-Leclerc, Dessen, Wouters, Stass, Greenwood, Ghanem, van den Oord et al.: "The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene. ..." in: Science translational medicine, Vol. 8, Issue 369, pp. 369ra177, (2016) (PubMed).

Target Details for PPP2R3B

Target: PPP2R3B (Protein Phosphatase 2A 48 KDa Regulatory Subunit (PPP2R3B))

Alternative Name: PPP2R3B (PPP2R3B Products)

Synonyms: NYREN8 antibody, PPP2R3L antibody, PPP2R3LY antibody, PR48 antibody, im:6895423 antibody, si:ch211-269e2.2 antibody, protein phosphatase 2 regulatory subunit B''beta antibody, serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta antibody, protein phosphatase 2, regulatory subunit B'', beta antibody, protein phosphatase 2 regulatory subunit B', beta L homeolog antibody, PPP2R3B antibody, LOC607103 antibody, ppp2r3b antibody, ppp2r3b.L antibody, Ppp2r3b antibody

Background: Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. PPP2R3B belongs to the B'' family. The B'' family has been further divided into subfamilies. PPP2R3B belongs to the beta subfamily of regulatory subunit B''.Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: NY-REN-8, PPP2R3L, PPP2R3LY, PR48, NYREN8
Protein Interaction Partner: DUSP12, UBC, PPP2R1A, CDC6, PPP2R1B, PPP2CA,
Protein Size: 575

Molecular Weight: 65 kDa

Gene ID: 28227

NCBI Accession: NM_013239, NP_037371

UniProt: Q9Y5P8

Pathways: PI3K-Akt Signaling, Mitotic G1-G1/S Phases