RAD23A antibody (Middle Region)

Catalog No. ABIN2775296

Product Details anti-RAD23A Antibody

Target: RAD23A (RAD23 Homolog A (RAD23A))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Horse, Guinea Pig, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAD23A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: GIPGSPEPEH GSVQESQVSE QPATEAAGEN PLEFLRDQPQ FQNMRQVIQQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against RAD23A. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RAD23A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 363 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RAD23A

Target: RAD23A (RAD23 Homolog A (RAD23A))

Alternative Name: RAD23A (RAD23A Products)

Synonyms: rad23a antibody, wu:fe11h06 antibody, zgc:92001 antibody, RAD23A antibody, HHR23A antibody, HR23A antibody, 2310040P19Rik antibody, AL024030 antibody, mHR23A antibody, RAD23 homolog A, nucleotide excision repair protein a antibody, RAD23 homolog A, nucleotide excision repair protein antibody, rad23aa antibody, RAD23A antibody, Rad23a antibody

Background: RAD23A is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
Alias Symbols: HHR23A, MGC111083
Protein Interaction Partner: USP25, ZBTB44, TRIP6, TRAF5, TRAF2, ZBTB8A, ANKRD40, FAM188A, TRIM54, NGLY1, CEP250, CEP76, UBC, SHFM1, vpr, XPC, DCTPP1, OGFOD1, UBA6, UBE2R2, TRNT1, HERC4, NT5C2, FKBP9, PCNA, HEXA, CDC34, GNPDA1, GTF3C4, USP5, WARS, TBCE, PYGL, PARP1, SH3RF2, PARK2, SQ
Protein Size: 363

Molecular Weight: 40 kDa

Gene ID: 5886

NCBI Accession: NM_005053, NP_005044

UniProt: P54725

Pathways: DNA Damage Repair