BAG2 antibody (C-Term)

Catalog No. ABIN2775278

Product Details anti-BAG2 Antibody

Target: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Rabbit, Zebrafish (Danio rerio), Dog, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAG2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against BAG2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human BAG2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 211 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-BAG2 antibody (ABIN2775278)

Yue, Zhao, Liu, Zhang, Yu, Wang, Zheng, Liu, Li, Feng, Hu: "BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function." in: eLife, Vol. 4, (2015) (PubMed).

Target Details for BAG2

Target: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Alternative Name: BAG2 (BAG2 Products)

Synonyms: bag2 antibody, MGC89300 antibody, BAG2 antibody, ATBAG2 antibody, BCL-2-associated athanogene 2 antibody, MTG10.13 antibody, MTG10_13 antibody, BAG-2 antibody, dJ417I1.2 antibody, zgc:64195 antibody, 2610042A13Rik antibody, BC016230 antibody, BCL2 associated athanogene 2 antibody, BCL-2-associated athanogene 2 antibody, BCL2-associated athanogene 2 antibody, Bcl2-associated athanogene 2 antibody, bag2 antibody, BAG2 antibody, Bag2 antibody

Background: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Alias Symbols: RP3-496N17.2, BAG-2, KIAA0576, MGC149462, dJ417I1.2
Protein Interaction Partner: BAG2, UBC, TP53, LGALS3BP, TUBGCP2, TUBG1, STIP1, TAB1, STUB1, DNAJB6, MLF2, TTC1, STXBP2, SGTA, DNAJB1, HSPA8, SHFM1, PINK1, RPA3, RPA2, RPA1, AHNAK, PARK2, LATS2, TARDBP, EGFR, BAG3, HDAC11, SOX2, NPM1, PAN2, WDR83, WDR77, CCAR2, METTL21B, DNAJC6, NOS2,
Protein Size: 211

Molecular Weight: 23 kDa

Gene ID: 9532

NCBI Accession: NM_004282, NP_004273

UniProt: O95816