BTRC antibody (C-Term)
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- Target See all BTRC Antibodies
- BTRC (beta-Transducin Repeat Containing (BTRC))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This BTRC antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- LVEHSGRVFR LQFDEFQIVS SSHDDTILIW DFLNDPAAHA EPPRSPSRTY
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 86%
- Characteristics
- This is a rabbit polyclonal antibody against Btrc. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product BTRC Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 605 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- BTRC (beta-Transducin Repeat Containing (BTRC))
- Alternative Name
- Btrc (BTRC Products)
- Synonyms
- BTRC antibody, Beta-TrCP antibody, betaTrCP antibody, btrcp antibody, btrcp1 antibody, fbw1a antibody, fbxw1 antibody, fbxw1a antibody, fwd1 antibody, btrc antibody, beta-TrCP antibody, BETA-TRCP antibody, FBW1A antibody, FBXW1 antibody, FBXW1A antibody, FWD1 antibody, bTrCP antibody, bTrCP1 antibody, beta-TrCP1 antibody, btrc-a antibody, Beta-Trcp1 antibody, Fbw1a antibody, HOS antibody, Slimb antibody, b-TrCP antibody, mKIAA4123 antibody, beta-transducin repeat containing E3 ubiquitin protein ligase antibody, beta-transducin repeat containing antibody, beta-TrCP antibody, beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog antibody, beta-transducin repeat containing protein antibody, BTRC antibody, btrc antibody, LOC100634006 antibody, Btrc antibody, btrc.S antibody
- Background
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Btrc is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1.
Alias Symbols: Beta-Trcp1, FWD1, Fbw1a, KIAA4123, Slimb, b-TrCP, beta-TrCP, mKIAA4123, HOS
Protein Interaction Partner: ZRANB1, Tpx2, Taz, Per2, Cul1, Skp1a, Reg1, Stat1, Nfe2l2, Per1, Htt, Cops2, Ikbkb, Nkx3-2, Cdc25b, Nfkbia, Gli2,
Protein Size: 605 - Molecular Weight
- 69 kDa
- Gene ID
- 12234
- NCBI Accession
- NM_001037758, NP_001032847
- UniProt
- Q3ULA2
- Pathways
- Cell Division Cycle, Hedgehog Signaling
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