DHX58 antibody (N-Term)

Catalog No. ABIN2775259

Product Details anti-DHX58 Antibody

Target: DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Horse, Guinea Pig, Cow, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DHX58 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AYVAKRHLET VDGAKVVVLV NRVHLVTQHG EEFRRMLDGR WTVTTLSGDM

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 91%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against DHX58. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DHX58

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 678 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DHX58

Target: DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Alternative Name: DHX58 (DHX58 Products)

Background: DHX58 is the negative regulator of host innate immune defense against viruses. The repressor domain of DHX58 interacts with DDX58 and negatively regulates DDX58-mediated signaling. Binds dsRNA produced during viral replication, in particuliar HCV RNA. Bin
Alias Symbols: D11LGP2, D11lgp2e, LGP2
Protein Interaction Partner: USP21, APP, UBD, NKRF, CDKN2AIP, AGO2, STAU2, DICER1, DHX30, XRN2, STAU1, EIF2AK2, EIF6, AP2B1,
Protein Size: 678

Molecular Weight: 76 kDa

Gene ID: 79132

NCBI Accession: NM_024119, NP_077024

UniProt: Q96C10