AKAP5 antibody (Middle Region)
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- Target See all AKAP5 Antibodies
- AKAP5 (A Kinase (PRKA) Anchor Protein 5 (AKAP5))
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Binding Specificity
- Middle Region
- Reactivity
- Human, Rat, Mouse, Cow, Dog, Pig, Saccharomyces cerevisiae, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This AKAP5 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- KQFLISAENE QVGVFANDNG FEDRTSEQYE TLLIETASSL VKNAIQLSIE
- Predicted Reactivity
- Cow: 86%, Dog: 86%, Horse: 86%, Human: 100%, Mouse: 79%, Pig: 86%, Rat: 79%, Yeast: 82%
- Characteristics
- This is a rabbit polyclonal antibody against AKAP5. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human AKAP5
- Top Product
- Discover our top product AKAP5 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 427 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- AKAP5 (A Kinase (PRKA) Anchor Protein 5 (AKAP5))
- Alternative Name
- AKAP5 (AKAP5 Products)
- Synonyms
- AKAP5 antibody, AKAP75 antibody, AKAP79 antibody, H21 antibody, AKAP antibody, P75 antibody, 3526401B18Rik antibody, AKAP 150 antibody, AKAP-5 antibody, AKAP150 antibody, BB098886 antibody, Gm258 antibody, P150 antibody, Akap79 antibody, A kinase (PRKA) anchor protein 5 antibody, A-kinase anchoring protein 5 antibody, AKAP5 antibody, Akap5 antibody
- Target Type
- Viral Protein
- Background
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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP5 is a member of the AKAP family. It binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AKAP75, AKAP79, H21
Protein Interaction Partner: PRKACB, PRKACA, UBC, PRKCA, CALM1, GABRB1, GABRB3, IQGAP1, DLG4, DLG1, KCNJ2, PRKAR2B, PRKAR2A, RET, PPP3CA, ADRB2, Gria1, Grin2b,
Protein Size: 427 - Molecular Weight
- 47 kDa
- Gene ID
- 9495
- NCBI Accession
- NM_004857, NP_004848
- UniProt
- P24588
- Pathways
- cAMP Metabolic Process
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