NR1I2 antibody (N-Term)
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- Target See all NR1I2 Antibodies
- NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))
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Binding Specificity
- N-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NR1I2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- KKEMIMSDEA VEERRALIKR KKSERTGTQP LGVQGLTEEQ RMMIRELMDA
- Predicted Reactivity
- Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against NR1I2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human NR1I2
- Top Product
- Discover our top product NR1I2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 434 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Induced CYP3A4 expression in confluent Huh7 hepatoma cells as a result of decreased cell proliferation and subsequent pregnane X receptor activation." in: Molecular pharmacology, Vol. 83, Issue 3, pp. 659-70, (2013) (PubMed).
: "Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-?B signaling pathway." in: The Journal of pharmacology and experimental therapeutics, Vol. 345, Issue 3, pp. 473-82, (2013) (PubMed).
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Induced CYP3A4 expression in confluent Huh7 hepatoma cells as a result of decreased cell proliferation and subsequent pregnane X receptor activation." in: Molecular pharmacology, Vol. 83, Issue 3, pp. 659-70, (2013) (PubMed).
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- Target
- NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))
- Alternative Name
- NR1I2 (NR1I2 Products)
- Synonyms
- BXR antibody, ONR1 antibody, PAR antibody, PAR1 antibody, PAR2 antibody, PARq antibody, PRR antibody, PXR antibody, SAR antibody, SXR antibody, PXR.1 antibody, PXR.2 antibody, PXR1 antibody, mPXR antibody, bxr antibody, nr1i2 antibody, onr1 antibody, xonr1 antibody, nuclear receptor subfamily 1 group I member 2 antibody, nuclear receptor subfamily 1, group I, member 2 antibody, nuclear receptor subfamily 1 group I member 2 S homeolog antibody, NR1I2 antibody, Nr1i2 antibody, nr1i2.S antibody, nr1i2 antibody
- Background
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NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. NR1I2 contains a zinc finger domain.NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
Alias Symbols: BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
Protein Interaction Partner: NCOA1, RPS6KB1, UBC, RBBP7, DDB1, UBR5, DYRK2, NCOR2, SDF4, NCOA3, TFAP2C, MAPK7, NFATC4, HSP90AA1, FGR, ATP6AP1, RXRA, RBCK1, NCOA2, SUMO1, SUMO2, SUMO3, NCOA6, SRC, RXRG, RXRB, CHMP1A, NUCB2, ACTN2, PPARGC1A, EIF3I, TADA3, NCOR1, PRMT1, NR1I2, PSMC5, PO
Protein Size: 434 - Molecular Weight
- 50 kDa
- Gene ID
- 8856
- NCBI Accession
- NM_003889, NP_003880
- UniProt
- O75469
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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