TJP1 antibody (Middle Region)

Catalog No. ABIN501576

Product Details anti-TJP1 Antibody

Target: TJP1 (Tight Junction Protein 1 (TJP1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Pig, Dog, Guinea Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TJP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: QNHVLKQPAV SHPGHRPDKE PNLTYEPQLP YVEKQASRDL EQPTYRYESS

Predicted Reactivity: Dog: 92%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 87%, Pig: 93%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against TJP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TJP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1668 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TJP1

Target: TJP1 (Tight Junction Protein 1 (TJP1))

Alternative Name: TJP1 (TJP1 Products)

Background: TJP1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. TJP1 may be involved in signal transduction at cell-cell junctions.This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene.
Alias Symbols: DKFZp686M05161, MGC133289, ZO-1
Protein Interaction Partner: VMP1, RAPGEF2, LATS2, TJP2, PAN2, DTNA, UBC, SCO2, VAPA, VAPB, ZPR1, NOTCH2, NDUFV2, NDUFS6, SUGP1, RTN4, STRN, PARD3, PARD6A, PRKCI, SIRT7, KHDRBS1, ELAVL1, SSTR3, Cdk1, TUBA1C, TUBB4A, VIM, SPTAN1, PLEC, KRT10, KRT8, KRT1, GJA1, FLNA, ANXA6, ACTN1, ACTN
Protein Size: 1668

Molecular Weight: 187 kDa

Gene ID: 7082

NCBI Accession: NM_175610, NP_783297

UniProt: Q07157

Pathways: Carbohydrate Homeostasis, Cell-Cell Junction Organization