TRIM63 antibody (Middle Region)

Catalog No. ABIN2774803

Product Details anti-TRIM63 Antibody

Target: TRIM63 (Tripartite Motif Containing 63 (TRIM63))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM63 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EQLDKSTKLV ETAIQSLDEP GGATFLLTAK QLIKSIVEAS KGCQLGKTEQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TRIM63. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TRIM63

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 353 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRIM63

Target: TRIM63 (Tripartite Motif Containing 63 (TRIM63))

Alternative Name: TRIM63 (TRIM63 Products)

Background: This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.
Alias Symbols: FLJ32380, IRF, MURF1, MURF2, RNF28, SMRZ
Protein Interaction Partner: UBE2D3, UBE2D1, UBC, TRIM63, USP37, ANKIB1, EPN1, ATXN3, EPS15, DCAF6, LMCD1, ANKRD1, NOMO1, GMEB1, NEBL, PIAS3, MRPL19, MYOT, PIAS2, SQSTM1, TCAP, PIAS1, UXT, UQCRC1, TTN, TNNI3, TNNI2, TNNI1, GFM1, TRIM55, MRPL41, MYOZ1, NEB, NDUFA1, MYBPC3, MYBPC1, EIF
Protein Size: 353

Molecular Weight: 40 kDa

Gene ID: 84676

NCBI Accession: NM_032588, NP_115977

UniProt: Q969Q1