EFTUD1 antibody (C-Term)

Catalog No. ABIN2774502

Product Details anti-EFTUD1 Antibody

Target: EFTUD1 (Elongation Factor Tu GTP Binding Domain Containing 1 (EFTUD1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EFTUD1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TTEEEYLHFG EKADSENQAR KYMNAVRKRK GLYVEEKIVE HAEKQRTLSK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against EFTUD1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human EFTUD1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1069 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EFTUD1

Target: EFTUD1 (Elongation Factor Tu GTP Binding Domain Containing 1 (EFTUD1))

Alternative Name: EFTUD1 (EFTUD1 Products)

Synonyms: FAM42A antibody, HsT19294 antibody, RIA1 antibody, 4932434J20Rik antibody, 6030468D11Rik antibody, AI451340 antibody, AU019507 antibody, AU022896 antibody, D7Ertd791e antibody, elongation factor like GTPase 1 antibody, elongation factor like GPTase 1 antibody, EFL1 antibody, Efl1 antibody

Background: EFTUD1 is involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, EFTUD1 triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. EFTUD1 has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits.
Alias Symbols: FAM42A, HsT19294, RIA1
Protein Interaction Partner: TP53RK, FKBP10, RPRD1B, OSGEP, PANK4, NSUN2, UFM1, KIAA1279, ACTR2, TPD52L2, RANGAP1, LPP, BAG1, UBC,
Protein Size: 1069

Molecular Weight: 117 kDa

Gene ID: 79631

NCBI Accession: NM_001040610, NP_001035700

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly