PMM2 antibody (Middle Region)

Catalog No. ABIN2774385

Product Details anti-PMM2 Antibody

Target: PMM2 (Phosphomannomutase 2 (PMM2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Guinea Pig, Dog, Horse, Cow, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PMM2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IEFRNGMLNV SPIGRSCSQE ERIEFYELDK KENIRQKFVA DLRKEFAGKG

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%

Characteristics: This is a rabbit polyclonal antibody against PMM2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 246 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PMM2

Target: PMM2 (Phosphomannomutase 2 (PMM2))

Alternative Name: PMM2 (PMM2 Products)

Background: The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I.
Alias Symbols: CDG1, CDG1a, CDGS, PMM 2
Protein Interaction Partner: ACY3, SUMO2, UBC, TAGLN3,
Protein Size: 246

Molecular Weight: 28 kDa

Gene ID: 5373

NCBI Accession: NM_000303, NP_000294

UniProt: O15305