CNTF Receptor alpha antibody (C-Term)
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- Target See all CNTF Receptor alpha (CNTFR) Antibodies
- CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))
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Binding Specificity
- C-Term
- Reactivity
- Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Guinea Pig, Sheep
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CNTF Receptor alpha antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- VAAHATPWTE EPRHLTTEAQ AAETTTSTTS SLAPPPTTKI CDPGELGSGG
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Sheep: 93%
- Characteristics
- This is a rabbit polyclonal antibody against CNTFR. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human CNTFR
- Top Product
- Discover our top product CNTFR Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 372 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))
- Alternative Name
- CNTFR (CNTFR Products)
- Synonyms
- CNTFR-alpha antibody, CNTFRALPHA antibody, Cntfralpha antibody, cb549 antibody, fj33e02 antibody, sb:cb549 antibody, wu:fj33e02 antibody, si:bz76a6.1 antibody, si:dz248f2.1 antibody, si:rp71-76a6.1 antibody, ciliary neurotrophic factor receptor antibody, ciliary neurotrophic factor receptor L homeolog antibody, CNTFR antibody, cntfr.L antibody, Cntfr antibody, cntfr antibody
- Background
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This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.
Alias Symbols: MGC1774
Protein Interaction Partner: HN1L, KRTAP4-12, CLCF1, CRLF1, PLSCR1, APPBP2, IL6ST, LIFR, CNTF,
Protein Size: 372 - Molecular Weight
- 41 kDa
- Gene ID
- 1271
- NCBI Accession
- NM_001842, NP_001833
- UniProt
- P26992
- Pathways
- JAK-STAT Signaling, Feeding Behaviour
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