APOE antibody (N-Term)
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- Target See all APOE Antibodies
- APOE (Apolipoprotein E (APOE))
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Binding Specificity
- N-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This APOE antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- KVLWAALLVT FLAGCQAKVE QAVETEPEPE LRQQTEWQSG QRWELALGRF
- Predicted Reactivity
- Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against APOE. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human APOE
- Top Product
- Discover our top product APOE Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 317 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain." in: Aging and disease, Vol. 7, Issue 3, pp. 267-77, (2016) (PubMed).
: "Apolipoprotein E pathology in vascular dementia." in: International journal of clinical and experimental pathology, Vol. 7, Issue 3, pp. 938-47, (2014) (PubMed).
: "Identification of an amino-terminal fragment of apolipoprotein E4 that localizes to neurofibrillary tangles of the Alzheimer's disease brain." in: Brain research, Vol. 1475, pp. 106-15, (2012) (PubMed).
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Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain." in: Aging and disease, Vol. 7, Issue 3, pp. 267-77, (2016) (PubMed).
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- Target
- APOE (Apolipoprotein E (APOE))
- Alternative Name
- APOE (APOE Products)
- Synonyms
- ad2 antibody, apoprotein antibody, im:7036787 antibody, wu:fb69a05 antibody, zgc:110064 antibody, apoe antibody, AI255918 antibody, AD2 antibody, LDLCQ5 antibody, LPG antibody, APOEA antibody, Apo-E antibody, apolipoprotein E antibody, apolipoprotein Ea antibody, apoe antibody, apoea antibody, Apoe antibody, APOE antibody
- Background
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Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AD2, MGC1571, apoprotein, LPG, LDLCQ5
Protein Interaction Partner: LCAT, ARFGAP1, ALB, C19orf52, LOXL4, PRAM1, MID1IP1, ANKH, FBXL12, FXYD7, ECSIT, PDCD4, IFIT5, MAST1, EPN2, PLEKHA6, CDC37, IQSEC1, LONP1, TYRO3, PRDX2, ST13, RPL4, RHEB, PSEN1, HTRA1, PCMT1, ZNF558, NOS3, IFIT3, GCDH, FOXG1, FARSA, ELAVL1, CYP2C18, CYP2C
Protein Size: 317 - Molecular Weight
- 34 kDa
- Gene ID
- 348
- NCBI Accession
- NM_000041, NP_000032
- UniProt
- P02649
- Pathways
- Regulation of Cell Size, Lipid Metabolism
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