CRYGC antibody (Middle Region)

Catalog No. ABIN2774014

Product Details anti-CRYGC Antibody

Target: CRYGC (Crystallin, gamma C (CRYGC))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Rabbit, Cow, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRYGC antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GLSDSIRSCC LIPQTVSHRL RLYEREDHKG LMMELSEDCP SIQDRFHLSE

Predicted Reactivity: Cow: 79%, Dog: 93%, Horse: 86%, Human: 100%, Rabbit: 86%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against CRYGC. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CRYGC

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 174 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CRYGC

Target: CRYGC (Crystallin, gamma C (CRYGC))

Alternative Name: CRYGC (CRYGC Products)

Synonyms: Cryg antibody, Cryg3 antibody, Len antibody, CCL antibody, CRYG3 antibody, CTRCT2 antibody, Cryg-5 antibody, ccl antibody, cryg3 antibody, MGC84008 antibody, CRYGC antibody, crystallin, gamma C antibody, crystallin gamma C antibody, crystallin gamma C L homeolog antibody, gamma-crystallin C antibody, Crygc antibody, CRYGC antibody, crygc.L antibody, LOC100069179 antibody

Background: Crystallins are the dominant structural components of the vertebrate eye lens.Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CCL, CRYG3
Protein Interaction Partner: MIP, HSPB2, HSPB1, CRYGD, CRYGC, CRYBB2, CRYAB, CRYAA,
Protein Size: 174

Molecular Weight: 21 kDa

Gene ID: 1420

NCBI Accession: NM_020989, NP_066269

UniProt: P07315