CTDSP2 antibody (Middle Region)
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- Target See all CTDSP2 Antibodies
- CTDSP2 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 (CTDSP2))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Rat, Mouse, Cow, Horse, Guinea Pig, Rabbit, Dog, Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CTDSP2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- ASYIFHPENA VPVQSWFDDM ADTELLNLIP IFEELSGAED VYTSLGQLRA
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 91%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against CTDSP2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human CTDSP2
- Top Product
- Discover our top product CTDSP2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 271 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- CTDSP2 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 (CTDSP2))
- Alternative Name
- CTDSP2 (CTDSP2 Products)
- Synonyms
- fb16c04 antibody, wu:fb16c04 antibody, zgc:77714 antibody, MGC68415 antibody, CTDSP2 antibody, OS4 antibody, PSR2 antibody, SCP2 antibody, AI586070 antibody, D10Ertd73e antibody, OS-4 antibody, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 antibody, CTD small phosphatase 2 L homeolog antibody, CTD small phosphatase 2 antibody, ctdsp2 antibody, ctdsp2.L antibody, CTDSP2 antibody, Ctdsp2 antibody
- Background
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CTDSP2 preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A.CTDSP2 negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. CTDSP2 is recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.CTDSP2 may contribute to the development of sarcomas.
Alias Symbols: OS4, PSR2, SCP2
Protein Interaction Partner: CDCA3, UBC, AR, SNAI1, POLR2A,
Protein Size: 271 - Molecular Weight
- 31 kDa
- Gene ID
- 10106
- NCBI Accession
- NM_005730, NP_005721
- UniProt
- O14595
- Pathways
- ER-Nucleus Signaling
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