MYCNOS antibody (N-Term)
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- Target See all MYCNOS products
- MYCNOS (MYCN Opposite Strand/antisense RNA (MYCNOS))
- Binding Specificity
- N-Term
- Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MYCNOS antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- WGGETDASNP APALTACCAA EREANVEQGL AGRLLLCNYE RRLVRRCKIA
- Predicted Reactivity
- Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against MYCNOS. It was validated on Western Blot.
- Purification
- Affinity Purified
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 109 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- MYCNOS (MYCN Opposite Strand/antisense RNA (MYCNOS))
- Alternative Name
- MYCNOS (MYCNOS Products)
- Synonyms
- MYCN-AS1 antibody, NCYM antibody, NYCM antibody, MYCN opposite strand antibody, MYCNOS antibody
- Background
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The N-myc oncogene has been implicated in the pathogenesis of a number of human tumors, including childhood neuroblastoma and adult small cell lung cancer. Complementary DNA clones derived from a transcription unit, N-cym, located on the opposite DNA strand to N-myc have been characterized. There is extensive overlap between the 5' ends of the two transcription units. The N-cym gene, which can encode a 109-amino acid protein, is expressed during fetal development, as well as in tumor cell lines containing amplified N-myc loci, where it is expressed at very high levels. Although other examples of overlapping, opposite-strand eukaryotic genes exist, N-myc and N-cym are unique in that they appear to be coregulated in tumor cell lines under basal growth conditions and in response to the differentiating agent retinoic acid. This coregulation suggests that their protein products may be functionally interrelated during normal development and oncogenesis.
Alias Symbols: NCYM, NYCM, MYCN-AS1
Protein Size: 109 - Molecular Weight
- 12 kDa
- Gene ID
- 10408
- NCBI Accession
- NM_006316, NP_006307
- UniProt
- P40205
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