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MYCNOS antibody (N-Term)

MYCNOS Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2773988
  • Target See all MYCNOS products
    MYCNOS (MYCN Opposite Strand/antisense RNA (MYCNOS))
    Binding Specificity
    N-Term
    Reactivity
    Human
    Host
    • 9
    Rabbit
    Clonality
    • 9
    Polyclonal
    Conjugate
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MYCNOS antibody is un-conjugated
    Application
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    WGGETDASNP APALTACCAA EREANVEQGL AGRLLLCNYE RRLVRRCKIA
    Predicted Reactivity
    Human: 100%
    Characteristics
    This is a rabbit polyclonal antibody against MYCNOS. It was validated on Western Blot.
    Purification
    Affinity Purified
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 109 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    MYCNOS (MYCN Opposite Strand/antisense RNA (MYCNOS))
    Alternative Name
    MYCNOS (MYCNOS Products)
    Synonyms
    MYCN-AS1 antibody, NCYM antibody, NYCM antibody, MYCN opposite strand antibody, MYCNOS antibody
    Background
    The N-myc oncogene has been implicated in the pathogenesis of a number of human tumors, including childhood neuroblastoma and adult small cell lung cancer. Complementary DNA clones derived from a transcription unit, N-cym, located on the opposite DNA strand to N-myc have been characterized. There is extensive overlap between the 5' ends of the two transcription units. The N-cym gene, which can encode a 109-amino acid protein, is expressed during fetal development, as well as in tumor cell lines containing amplified N-myc loci, where it is expressed at very high levels. Although other examples of overlapping, opposite-strand eukaryotic genes exist, N-myc and N-cym are unique in that they appear to be coregulated in tumor cell lines under basal growth conditions and in response to the differentiating agent retinoic acid. This coregulation suggests that their protein products may be functionally interrelated during normal development and oncogenesis.
    Alias Symbols: NCYM, NYCM, MYCN-AS1
    Protein Size: 109
    Molecular Weight
    12 kDa
    Gene ID
    10408
    NCBI Accession
    NM_006316, NP_006307
    UniProt
    P40205
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