MRVI1 antibody (N-Term)

Catalog No. ABIN2773963

Product Details anti-MRVI1 Antibody

Target: MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))

Binding Specificity: N-Term

Reactivity: Human, Horse, Mouse, Rabbit, Cow, Dog, Guinea Pig, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRVI1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LVNDQLPDIS ISEEDKKKNL ALLEEAKLVS ERFLTRRGRK SRSSPGDSPS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MRVI1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MRVI1

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MRVI1

Target: MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))

Alternative Name: MRVI1 (MRVI1 Products)

Synonyms: BB115629 antibody, Irag antibody, Ris1 antibody, IRAG antibody, JAW1L antibody, MRV integration site 1 antibody, murine retrovirus integration site 1 homolog antibody, Mrvi1 antibody, MRVI1 antibody

Background: This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
Protein Interaction Partner: MME, PRKG1, ITPR1,
Protein Size: 803

Molecular Weight: 88 kDa

Gene ID: 10335