PRTFDC1 antibody (Middle Region)

Catalog No. ABIN2773930

Product Details anti-PRTFDC1 Antibody

Target: PRTFDC1 (phosphoribosyl Transferase Domain Containing 1 (PRTFDC1))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Pig, Horse, Rabbit, Zebrafish (Danio rerio), Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRTFDC1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MKALLSNIEK YKPNMIKVAS LLVKRTSRSD GFRPDYAGFE IPNLFVVGYA

Predicted Reactivity: Dog: 92%, Horse: 100%, Human: 100%, Pig: 100%, Rabbit: 77%, Rat: 92%, Zebrafish: 77%

Characteristics: This is a rabbit polyclonal antibody against PRTFDC1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PRTFDC1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 225 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PRTFDC1 antibody (ABIN2773930)

Suzuki, Imoto, Pimkhaokham, Nakagawa, Kamata, Kozaki, Amagasa, Inazawa: "PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation." in: Oncogene, Vol. 26, Issue 57, pp. 7921-32, (2007) (PubMed).

Target Details for PRTFDC1

Target: PRTFDC1 (phosphoribosyl Transferase Domain Containing 1 (PRTFDC1))

Alternative Name: PRTFDC1 (PRTFDC1 Products)

Synonyms: HHGP antibody, HPRT antibody, hprt1 antibody, hprt1l antibody, zgc:55561 antibody, zgc:86771 antibody, MGC80959 antibody, OTTMUSG00000011667 antibody, Prtfdc1 antibody, phosphoribosyl transferase domain containing 1 antibody, phosphoribosyl transferase domain containing 1 L homeolog antibody, phosphoribosyltransferase domain containing 1 pseudogene antibody, PRTFDC1 antibody, prtfdc1 antibody, Prtfdc1 antibody, prtfdc1.L antibody, Gm13377 antibody

Background: PRTFDC1 belongs to the purine/pyrimidine phosphoribosyltransferase family. Epigenetic silencing of PRTFDC1 by hypermethylation of the CpG islands leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis.
Alias Symbols: FLJ11888, HHGP
Protein Interaction Partner: LGALS9B, EEF2KMT, MCMBP, GNPDA1, EPM2AIP1, TCL1A, HPRT1, UBC, RTN3, FLAD1, NIF3L1, DTNB, STAT5A, EWSR1,
Protein Size: 225

Molecular Weight: 26 kDa

Gene ID: 56952

NCBI Accession: NM_020200, NP_064585

UniProt: Q9NRG1

Pathways: Ribonucleoside Biosynthetic Process