ST14 antibody (C-Term)

Catalog No. ABIN2773910

Product Details anti-ST14 Antibody

Target: ST14 (Suppression of Tumorigenicity 14 (Colon Carcinoma) (ST14))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Dog, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ST14 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: SHVFPAGKAI WVTGWGHTQY GGTGALILQK GEIRVINQTT CENLLPQQIT

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against ST14. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ST14

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 855 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ST14 antibody (ABIN2773910)

Landova Sulcova, Zahradnicek, Dumkova, Dosedelova, Krivanek, Hampl, Kavkova, Zikmund, Gregorovicova, Sedmera, Kaiser, Tucker, Buchtova: "Developmental mechanisms driving complex tooth shape in reptiles." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 249, Issue 4, pp. 441-464, (2020) (PubMed).

Target Details for ST14

Target: ST14 (Suppression of Tumorigenicity 14 (Colon Carcinoma) (ST14))

Alternative Name: ST14 (ST14 Products)

Synonyms: HAI antibody, MT-SP1 antibody, MTSP1 antibody, PRSS14 antibody, SNC19 antibody, TADG15 antibody, TMPRSS14 antibody, XMT-SP1 antibody, hai antibody, mt-sp1 antibody, mtsp1 antibody, prss14 antibody, snc19 antibody, st14 antibody, st14a antibody, tadg15 antibody, tmprss1 antibody, Epithin antibody, Prss14 antibody, Tmprss14 antibody, mCAP3 antibody, matriptase antibody, suppression of tumorigenicity 14 antibody, suppression of tumorigenicity 14 L homeolog antibody, suppression of tumorigenicity 14 (colon carcinoma) antibody, ST14 antibody, st14.L antibody, St14 antibody

Background: ST14 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.
Alias Symbols: HAI, MT-SP1, MTSP-1, MTSP1, PRSS14, SNC19, TADG-15, TADG15, TMPRSS14
Protein Interaction Partner: UBC, RGS16, PDGFC, CDCP1, SPINT1, F2RL1, PLAU, HGF,
Protein Size: 855

Molecular Weight: 95 kDa

Gene ID: 6768

NCBI Accession: NM_021978

UniProt: Q9Y5Y6