SEC63 antibody (C-Term)
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- Target See all SEC63 Antibodies
- SEC63 (SEC63 Homolog (SEC63))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Dog, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Cow, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SEC63 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- WWLYIADRKE QTLISMPYHV CTLKDTEEVE LKFPAPGKPG NYQYTVFLRS
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
- Characteristics
- This is a rabbit polyclonal antibody against SEC63. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human SEC63
- Top Product
- Discover our top product SEC63 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 760 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SEC63 (SEC63 Homolog (SEC63))
- Alternative Name
- SEC63 (SEC63 Products)
- Synonyms
- DNAJC23 antibody, ERdj2 antibody, PRO2507 antibody, SEC63L antibody, 5730478J10Rik antibody, AI649014 antibody, AW319215 antibody, SEC63-like antibody, zgc:92718 antibody, SEC63 homolog, protein translocation regulator antibody, SEC63-like (S. cerevisiae) antibody, SEC63 homolog, protein translocation regulator L homeolog antibody, SEC63 antibody, Sec63 antibody, sec63 antibody, sec63.L antibody
- Background
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The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. SEC63 and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. SEC63 is an integral membrane protein located in the rough ER.The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.
Alias Symbols: ERdj2, PRO2507, SEC63L, DNAJC23
Protein Interaction Partner: UBC, IRF1, SEC61B, SEC62, GSTK1,
Protein Size: 760 - Molecular Weight
- 88 kDa
- Gene ID
- 11231
- NCBI Accession
- NM_007214, NP_009145
- UniProt
- Q9UGP8
- Pathways
- ER-Nucleus Signaling
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