TMEM48 antibody (Middle Region)

Catalog No. ABIN2773878

Product Details anti-TMEM48 Antibody

Target: TMEM48 (Transmembrane Protein 48 (TMEM48))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM48 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PPIIKYLALQ DLMLLSQYSP SRRQEVFSLS QPGGHPHNWT AISRECLNLL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against TMEM48. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TMEM48

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 674 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TMEM48 antibody (ABIN2773878)

Tarazón, Rivera, Roselló-Lletí, Molina-Navarro, Sánchez-Lázaro, España, Montero, Lago, González-Juanatey, Portolés: "Heart failure induces significant changes in nuclear pore complex of human cardiomyocytes." in: PLoS ONE, Vol. 7, Issue 11, pp. e48957, (2012) (PubMed).

Target Details for TMEM48

Target: TMEM48 (Transmembrane Protein 48 (TMEM48))

Alternative Name: TMEM48 (TMEM48 Products)

Synonyms: 2810475A17Rik antibody, AI450313 antibody, Tmem48 antibody, NET3 antibody, TMEM48 antibody, tmem48 antibody, wu:fk93f04 antibody, zgc:55636 antibody, Xndr antibody, NDC1 transmembrane nucleoporin antibody, NDC1 transmembrane nucleoporin S homeolog antibody, Xrcc1 N-terminal domain containing 1 antibody, Ndc1 antibody, NDC1 antibody, ndc1 antibody, ndc1.S antibody, Xndc1 antibody

Background: TMEM48 is a component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. TMEM48 is required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
Alias Symbols: FLJ10407, FLJ12556, FLJ34120, NDC1, RP4-654H19.1, NET3, TMEM48
Protein Interaction Partner: UBC, Ndc1, NUP93,
Protein Size: 674

Molecular Weight: 76 kDa

Gene ID: 55706

NCBI Accession: NM_018087, NP_060557

UniProt: Q9BTX1