IL9 Receptor antibody

Catalog No. ABIN2749221

Product Details anti-IL9 Receptor Antibody

Target: IL9 Receptor (IL9R) (Interleukin 9 Receptor (IL9R))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL9 Receptor antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Functional Studies (Func)

Specificity: The mouse monoclonal antibody AH9R7 recognizes an extracellular epitope of CD129 / IL-9R alpha, a 57 kDa type I transmembrane glycoprotein expressed at low levels by lymphocytes, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons.

Cross-Reactivity (Details): Human

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Endotoxin Level: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunogen: Human CD129-transfected cell line

Clone: AH9R7

Isotype: IgG2b kappa

Application Details

Application Notes: Functional application: Blocking.
Flow cytometry: It is recommended to use bright fluorochromes or signal multiplying detection.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Preservative: Azide free

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

References for anti-IL9 Receptor antibody (ABIN2749221)

Pilette, Ouadrhiri, Van Snick, Renauld, Staquet, Vaerman, Sibille: "Oxidative burst in lipopolysaccharide-activated human alveolar macrophages is inhibited by interleukin-9." in: The European respiratory journal, Vol. 20, Issue 5, pp. 1198-205, (2002) (PubMed).

De Smedt, Verhasselt, Kerre, Vanhecke, Naessens, Leclercq, Renauld, Van Snick, Plum: "Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1761-7, (2000) (PubMed).

Target Details for IL9 Receptor

Target: IL9 Receptor (IL9R) (Interleukin 9 Receptor (IL9R))

Alternative Name: CD129 / IL-9R alpha (IL9R Products)

Synonyms: CD129 antibody, IL-9R antibody, interleukin 9 receptor antibody, IL9R antibody, Il9r antibody

Background: Interleukin 9 receptor,CD129 serves as the high affinity alpha subunit of IL-9 receptor. It associates with CD132, the common gamma chain shared by receptors of many different cytokines. CD129 is expressed at low levels by T and B cells, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons. Its signaling (through JAK/STAT pathways) results in proliferative and anti-apoptotic response, which is critical e.g. for intrathymic T cell development and survival of various cell types. The gene for CD129 is located at the pseudoautosomal regions of X and Y chromosomes and it may be related with the development of asthma.,IL9R

Gene ID: 3581

UniProt: Q01113

Pathways: JAK-STAT Signaling, Growth Factor Binding