CD68 antibody
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- Target See all CD68 Antibodies
- CD68 (CD68 Molecule (CD68))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD68 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- The mouse monoclonal antibody Y1/82A recognizes CD68 (LAMP4), a 110 kDa glycoprotein expressed mainly in cytoplasmic granules of monocytes/macrophages, granulocytes, and dendritic cells.
- Cross-Reactivity (Details)
- Human
- Purification
- Purified by protein-A affinity chromatography.
- Purity
- > 95 % (by SDS-PAGE)
- Immunogen
- Lysosomal contents of lung macrophages
- Clone
- Y1-82A
- Isotype
- IgG2b
- Top Product
- Discover our top product CD68 Primary Antibody
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- Application Notes
- Flow cytometry: Recommended dilution: 2-6 μg/mL. Extracellular and intracellular staining.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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Characterization of bone marrow derived cells in the substantia propria of the human conjunctiva." in: Investigative ophthalmology & visual science, Vol. 48, Issue 10, pp. 4476-81, (2007) (PubMed).
: "Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation." in: Pediatric research, Vol. 56, Issue 1, pp. 79-87, (2004) (PubMed).
: "The Common vaccine adjuvant aluminum hydroxide up-regulates accessory properties of human monocytes via an interleukin-4-dependent mechanism." in: Infection and immunity, Vol. 69, Issue 2, pp. 1151-9, (2001) (PubMed).
: "CD68 reactivity of non-macrophage derived tumours in cytological specimens." in: Journal of clinical pathology, Vol. 46, Issue 4, pp. 334-6, (1993) (PubMed).
: "Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins." in: Blood, Vol. 81, Issue 6, pp. 1607-13, (1993) (PubMed).
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Characterization of bone marrow derived cells in the substantia propria of the human conjunctiva." in: Investigative ophthalmology & visual science, Vol. 48, Issue 10, pp. 4476-81, (2007) (PubMed).
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- Target
- CD68 (CD68 Molecule (CD68))
- Alternative Name
- CD68 (CD68 Products)
- Synonyms
- Lamp4 antibody, Scard1 antibody, gp110 antibody, GP110 antibody, LAMP4 antibody, SCARD1 antibody, CD68 molecule antibody, CD68 antigen antibody, Cd68 molecule antibody, CD68 antibody, Cd68 antibody
- Background
- CD68 Molecule,CD68 (also known as LAMP4 or SCARD1) is a 110 kDa type I transmembrane glycoprotein of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family and the scavenger receptor family. Although CD68 primarily localizes to lysosomes and endosomes, its fraction circulates to the cell surface. By the heavily glycosylated extracellular domain CD68 binds to tissue- and organ-specific lectins or selectins. It is expressed mainly in cytoplasmic granules of monocytes/macrophages, granulocytes, and dendritic cells, but also e.g. in a proportion of epithelial tumours (diagnosis of poorly differentiated neoplasms).,GP110, LAMP4, SCARD1
- Gene ID
- 968
- UniProt
- P34810
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