DLL4 antibody

Catalog No. ABIN2749212

Product Details anti-DLL4 Antibody

Target: DLL4 (delta-Like 4 (DLL4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DLL4 antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func)

Specificity: The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.

Cross-Reactivity (Details): Human

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Endotoxin Level: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunogen: recombinant soluble human DLL4

Clone: MHD4-46

Isotype: IgG1 kappa

Application Details

Application Notes: Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Preservative: Azide free

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

References for anti-DLL4 antibody (ABIN2749212)

Sekine, Koyanagi, Koyama, Hozumi, Chiba, Yagita: "Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes." in: Arthritis research & therapy, Vol. 14, Issue 2, pp. R45, (2012) (PubMed).

Oishi, Sunamura, Egawa, Motoi, Unno, Furukawa, Habib, Yagita: "Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer." in: Pancreas, Vol. 39, Issue 6, pp. 897-903, (2010) (PubMed).

Yamanda, Ebihara, Asada, Okazaki, Niu, Ebihara, Koyanagi, Yamaguchi, Yagita, Arai: "Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade." in: Blood, Vol. 113, Issue 15, pp. 3631-9, (2009) (PubMed).

Target Details for DLL4

Target: DLL4 (delta-Like 4 (DLL4))

Alternative Name: DLL4 (DLL4 Products)

Synonyms: hdelta2 antibody, Delta4 antibody, si:ch211-244p18.5 antibody, zgc:136596 antibody, delta like canonical Notch ligand 4 antibody, delta-like 4 (Drosophila) antibody, DLL4 antibody, Dll4 antibody, dll4 antibody

Background: Delta like canonical Notch ligand 4,DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.,Delta like ligand 4, AOS6, canonical Notch ligand 4

Gene ID: 54567

UniProt: Q9NR61

Pathways: Notch Signaling