CD160 antibody

Catalog No. ABIN2749166

Product Details anti-CD160 Antibody

Target: CD160

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD160 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Specificity: The mouse monoclonal antibody BY55 recognizes an extracellular epitope of CD160, a 27 kDa glycoprotein expressed on NK cells, NK-T cells, intestinal intraepithelial lymphocytes, TCR-gamma/delta T cells and a small population of TCR-alpha/beta T cells. The antibody detects both GPI-anchored and transmembrane form of CD160.

Cross-Reactivity (Details): Human

Purification: Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).

Purity: > 95 % (by SDS-PAGE)

Immunogen: Human NK cell line YT2C2

Clone: BY55

Isotype: IgM kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

References for anti-CD160 antibody (ABIN2749166)

Giustiniani, Bensussan, Marie-Cardine: "Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 1, pp. 63-71, (2008) (PubMed).

Merino, Ramírez, Moreno, Toledo, Fernández, Sánchez-Ibarrola: "BY55/CD160 cannot be considered a cytotoxic marker in cytomegalovirus-specific human CD8(+) T cells." in: Clinical and experimental immunology, Vol. 149, Issue 1, pp. 87-96, (2007) (PubMed).

Target Details for CD160

Target: CD160

Alternative Name: CD160 (CD160 Products)

Background: CD160 Molecule,CD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent.,NK1, NK28

Gene ID: 11126

UniProt: O95971