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CCR5 antibody (AA 1-22) (APC)

CCR5 Reactivity: Human FACS Host: Mouse Monoclonal T21-8 APC
Catalog No. ABIN2749115
  • Target See all CCR5 Antibodies
    CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
    Binding Specificity
    • 16
    • 13
    • 11
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-22
    Reactivity
    • 145
    • 44
    • 36
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 106
    • 31
    • 13
    • 4
    • 1
    Mouse
    Clonality
    • 109
    • 40
    • 3
    Monoclonal
    Conjugate
    • 83
    • 13
    • 11
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CCR5 antibody is conjugated to APC
    Application
    • 93
    • 69
    • 57
    • 21
    • 17
    • 17
    • 16
    • 14
    • 14
    • 13
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Flow Cytometry (FACS)
    Specificity
    The mouse monoclonal antibody T21/8 recognizes an extracellular epitope on the N-teminus of CD195, an approximately 45 kDa G-protein coupled receptor 1 family protein expressed on resting T cells, monocytes, macrophages, and immature dendritic cells.
    Cross-Reactivity (Details)
    Human
    Purification
    Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    CCR5 peptide (Met1-Lys22) KLH conjugate
    Clone
    T21-8
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CCR5 Primary Antibody
  • Application Notes
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Comment

    The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Mascalchi, Lamort, Salomé, Dumas: "Single Particle Tracking reveals two distinct environments for CD4 receptors at the surface of living T lymphocytes." in: Biochemical and biophysical research communications, Vol. 417, Issue 1, pp. 409-13, (2012) (PubMed).

    Monde, Maeda, Tanaka, Harada, Yusa: "Gp120 V3-dependent impairment of R5 HIV-1 infectivity due to virion-incorporated CCR5." in: The Journal of biological chemistry, Vol. 282, Issue 51, pp. 36923-32, (2007) (PubMed).

    Hüttenrauch, Pollok-Kopp, Oppermann: "G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers." in: The Journal of biological chemistry, Vol. 280, Issue 45, pp. 37503-15, (2005) (PubMed).

    Pollok-Kopp, Schwarze, Baradari, Oppermann: "Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies." in: The Journal of biological chemistry, Vol. 278, Issue 4, pp. 2190-8, (2003) (PubMed).

  • Target
    CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
    Alternative Name
    CD195 / CCR5 (CCR5 Products)
    Synonyms
    CC-CKR-5 antibody, CCCKR5 antibody, CCR-5 antibody, CD195 antibody, CKR-5 antibody, CKR5 antibody, CMKBR5 antibody, IDDM22 antibody, Ckr5 antibody, Cmkbr5 antibody, CCR1-L antibody, GPCR antibody, CCR5 antibody, AM4-7 antibody, C-C motif chemokine receptor 5 (gene/pseudogene) antibody, chemokine (C-C motif) receptor 5 antibody, C-C motif chemokine receptor 5 antibody, CCR5 antibody, Ccr5 antibody
    Background
    C-C motif chemokine receptor 5,CD195 / CCR5 (also known as CKR-5) is a receptor for inflammatory CC-chemokines (characterized by a pair of adjacent cysteine residues), such as MIP-1 alpha, MIP-1 beta, or RANTES. It is a G protein-associated seven-pass transmembrane protein expressed on resting T cells with memory/effector phenotype, monocytes, macrophages and immature dendritic cells. This chemokine receptor regulates the activation and directed migration of leukocytes. Importantly, along with CD4, CD195 / CCR5 functions as a major receptor for HIV. Their ligand is the viral glycoprotein gp120.,CKR5, CCR5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5
    Gene ID
    1234
    UniProt
    P51681
    Pathways
    Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
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