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PCLO antibody

PCLO Reactivity: Human WB, FACS Host: Mouse Monoclonal PCLO-01 unconjugated
Catalog No. ABIN2749094
  • Target See all PCLO Antibodies
    PCLO (Piccolo (Presynaptic Cytomatrix Protein) (PCLO))
    Reactivity
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 6
    • 1
    Mouse
    Clonality
    • 4
    • 3
    Monoclonal
    Conjugate
    • 5
    • 2
    This PCLO antibody is un-conjugated
    Application
    • 6
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Specificity
    The mouse monoclonal antibody PCLO-01 recognizes PCLO (Piccolo), a more than 400 kDa multidomain protein expressed mainly in the presynaptic cytoplasmatic matrix of the neurons.
    Cross-Reactivity (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    Human recombinant PCLO protein
    Clone
    PCLO-01
    Isotype
    IgG1
    Top Product
    Discover our top product PCLO Primary Antibody
  • Application Notes
    Flow cytometry: Recommended dilution: 1-5 μg/mL, intracellular staining.
    Western blotting: A small splice variant of PCLO can be analyzed by Western blotting, however, the whole protein is too large (over 400 kDa) to be successfully processed by SDS PAAGE.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Target
    PCLO (Piccolo (Presynaptic Cytomatrix Protein) (PCLO))
    Alternative Name
    PCLO (PCLO Products)
    Synonyms
    pclo antibody, wu:fj53e09 antibody, Acz antibody, Pico antibody, mKIAA0559 antibody, aczonin antibody, PCLO antibody, ACZ antibody, piccolo presynaptic cytomatrix protein antibody, piccolo presynaptic cytomatrix protein a antibody, piccolo (presynaptic cytomatrix protein) antibody, PCLO antibody, pcloa antibody, Pclo antibody, LOC768552 antibody
    Background
    Piccolo presynaptic cytomatrix protein,PCLO (piccolo, also known as aczonin) is a large (more than 400 kDa) multidomain protein of the presynaptic cytomatrix in neurons, that is present in all vertebrate synapses, but is absent from invertebrates. It contains zinc finger and coiled-coil sequences, as well as N-terminal glutamine-rich sequence, and C-terminal PDZ domain followed by two C2 domains (C2A and C2B). In vitro binding and transfection experiments suggested that PCLO binds to multiple proteins including profilin and L-type calcium channels. It is involved in neurotransmitter release and insulin secretion.,ACZ, PCH3, piccolo, aczonin
    Gene ID
    27445
    UniProt
    Q9Y6V0
    Pathways
    Hormone Transport, Synaptic Vesicle Exocytosis
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