PDE5A antibody (C-Term)

Catalog No. ABIN2747175

Product Details anti-PDE5A Antibody

Target: PDE5A (phosphodiesterase 5A, cGMP-Specific (PDE5A))

Binding Specificity: AA 825-875, C-Term

Reactivity: Human, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE5A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Confocal Microscopy (CM)

Purification: Affinity Purified

Immunogen: Synthetic peptide common to all PDE5A variants taken within amino acid region 825-875 on human PDE5A protein.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.55-0.60 μg/μL

References for anti-PDE5A antibody (ABIN2747175)

Carøe Nordgaard, Kruse, Gammeltoft, Kruuse: "Role of Ser102 and Ser104 as regulators of cGMP hydrolysis by PDE5A." in: PLoS ONE, Vol. 9, Issue 9, pp. e107627, (2015) (PubMed).

Rajagopal, Nalli, Kumar, Bhattacharya, Hu, Mahavadi, Grider, Murthy: "Cytokine-induced S-nitrosylation of soluble guanylyl cyclase and expression of phosphodiesterase 1A contribute to dysfunction of longitudinal smooth muscle relaxation." in: The Journal of pharmacology and experimental therapeutics, Vol. 352, Issue 3, pp. 509-18, (2015) (PubMed).

Kedia, Ückert, Oelke, Sonnenberg, Sohn, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human male urethra." in: Urology, Vol. 85, Issue 4, pp. 964.e1-6, (2015) (PubMed).

Witting, Kruuse, Nyhuus, Prahm, Citirak, Lundgaard, von Huth, Vejlstrup, Lindberg, Krag, Vissing: "Effect of sildenafil on skeletal and cardiac muscle in Becker muscular dystrophy." in: Annals of neurology, Vol. 76, Issue 4, pp. 550-7, (2014) (PubMed).

Ückert, Oelke, Albrecht, Breitmeier, Kuczyk, Hedlund: "Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5)." in: International journal of impotence research, Vol. 23, Issue 5, pp. 206-12, (2012) (PubMed).

Ückert, Waldkirch, Sonnenberg, Sandner, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human seminal vesicles." in: The journal of sexual medicine, Vol. 8, Issue 11, pp. 3058-65, (2012) (PubMed).

Mietens, Tasch, Feuerstacke, Eichner, Volkmann, Schermuly, Grimminger, Müller, Middendorff: "Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not." in: Molecular and cellular endocrinology, Vol. 349, Issue 2, pp. 145-53, (2012) (PubMed).

Luong, Rey-Perra, Vadivel, Gilmour, Sauve, Koonen, Walker, Todd, Gressens, Kassiri, Nadeem, Morgan, Eaton, Dyck, Archer, Thébaud: "Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia." in: Circulation, Vol. 123, Issue 19, pp. 2120-31, (2011) (PubMed).

Sasseville, Côté, Gagnon, Richard: "Up-regulation of 3'5'-cyclic guanosine monophosphate-specific phosphodiesterase in the porcine cumulus-oocyte complex affects steroidogenesis during in vitro maturation." in: Endocrinology, Vol. 149, Issue 11, pp. 5568-76, (2009) (PubMed).

Albrecht, Uckert, Oelke, Andersson, Jonas, Tröger, Hedlund: "Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human vagina: a potential forensic value?" in: Journal of forensic and legal medicine, Vol. 14, Issue 5, pp. 270-4, (2007) (PubMed).

Ückert, Oelke, Albrecht, Stief, Jonas, Hedlund: "Immunohistochemical description of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human labia minora." in: The journal of sexual medicine, Vol. 4, Issue 3, pp. 602-608, (2007) (PubMed).

Liu, Xin, Xin, Yuan, Tian, Guo: "Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats." in: Asian journal of andrology, Vol. 7, Issue 4, pp. 381-8, (2006) (PubMed).

Werkström, Svensson, Andersson, Hedlund: "Phosphodiesterase 5 in the female pig and human urethra: morphological and functional aspects." in: BJU international, Vol. 98, Issue 2, pp. 414-23, (2006) (PubMed).

Uckert, Oelke, Waldkirch, Stief, Albrecht, Tröger, Jonas, Andersson, Hedlund: "Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves." in: Urology, Vol. 65, Issue 3, pp. 604-10, (2005) (PubMed).

Wang, Gang Zhang, Lan Zhang, Chopp: "Activation of the PI3-K/Akt pathway mediates cGMP enhanced-neurogenesis in the adult progenitor cells derived from the subventricular zone." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 25, Issue 9, pp. 1150-8, (2005) (PubMed).

Monfort, Muñoz, Felipo: "Chronic hyperammonemia in vivo impairs long-term potentiation in hippocampus by altering activation of cyclic GMP-dependent-protein kinase and of phosphodiesterase 5." in: Journal of neurochemistry, Vol. 94, Issue 4, pp. 934-42, (2005) (PubMed).

Target Details for PDE5A

Target: PDE5A (phosphodiesterase 5A, cGMP-Specific (PDE5A))

Alternative Name: PDE5A (PDE5A Products)

Synonyms: CGB-PDE antibody, CN5A antibody, PDE5 antibody, PDE5A2 antibody, Cgbpde antibody, Cn5n antibody, Pde5 antibody, Pde5a1 antibody, PDE5A antibody, pde5a antibody, cgb-pde antibody, cn5a antibody, pde5 antibody, pde5a1 antibody, phosphodiesterase 5A antibody, phosphodiesterase 5A, cGMP-specific antibody, phosphodiesterase 5A S homeolog antibody, phosphodiesterase 5A, cGMP-specific, b antibody, PDE5A antibody, Pde5a antibody, pde5a.S antibody, pde5ab antibody, pde5a antibody

UniProt: O76074

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling