PDE4D antibody

Catalog No. ABIN2747152

Product Details anti-PDE4D Antibody

Target: PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE4D antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Confocal Microscopy (CM)

Purification: Affinity Purified

Immunogen: Synthetic peptide selective for all PDE4D variants.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.57 μg/μL

References for anti-PDE4D antibody (ABIN2747152)

Massimi, Cardarelli, Galli, Giardi, Ragusa, Panera, Cinque, Cifone, Biagioni, Giorgi: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Guo, Lin, Zhao, Zhang, Wei, Wang, Wang: "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." in: Neuroscience, Vol. 263, pp. 1-14, (2014) (PubMed).

Zhai, Chang, Wei, Liu, Leblais, Fischmeister, Ji: "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." in: Cellular signalling, Vol. 26, Issue 5, pp. 1001-10, (2014) (PubMed).

Dong, Guo, Ye, Hare: "Presynaptic inhibition by α2 receptor/adenylate cyclase/PDE4 complex at retinal rod bipolar synapse." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 28, pp. 9432-40, (2014) (PubMed).

Wang, Zhang, Liu, Zhao, Zhang, Yuan, An, Li, Wang, Qin, Wilson, ODonnell, Zhang, Li: "RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects." in: British journal of pharmacology, Vol. 168, Issue 4, pp. 1001-14, (2013) (PubMed).

Michalski, Kanaji, Liu, Nogel, Wang, Basma, Nakanishi, Sato, Gunji, Fahrid, Nelson, Muller, Holz, Magnussen, Rabe, Toews, Rennard: "Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4." in: American journal of respiratory cell and molecular biology, Vol. 47, Issue 6, pp. 729-37, (2013) (PubMed).

Al-Tawashi, Jung, Liu, Su, Qin: "Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity." in: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 14644-58, (2012) (PubMed).

Abusnina, Alhosin, Keravis, Muller, Fuhrmann, Bronner, Lugnier: "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." in: Cellular signalling, Vol. 23, Issue 1, pp. 152-60, (2011) (PubMed).

Genders, Bradley, Rattigan, Richards: "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." in: American journal of physiology. Endocrinology and metabolism, Vol. 301, Issue 2, pp. E342-50, (2011) (PubMed).

Yougbare, Morin, Senouvo, Sirois, Albadine, Lugnier, Rousseau: "NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 4, pp. L441-50, (2011) (PubMed).

Gregg, Steppan, Gonzalez, Champion, Phan, Nyhan, Shoukas, Hare, Barouch, Berkowitz: "β2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation." in: Anesthesia and analgesia, Vol. 111, Issue 4, pp. 870-7, (2010) (PubMed).

Zhang, Huang, Masood, Stolinski, Li, Zhang, Dlaboga, Jin, Conti, ODonnell: "Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 33, Issue 7, pp. 1611-23, (2008) (PubMed).

Nomura-Furuwatari, Wakitani, Hashimoto, Imai, Ohta, Nakagawa, Nakao, Takayama, Manaka, Takaoka: "Expression profiles of phosphodiesterase 4D splicing variants in osteoblastic cells." in: Journal of bone and mineral metabolism, Vol. 26, Issue 2, pp. 152-8, (2008) (PubMed).

Fujita, Imaizumi, DSa, Zoghbi, Crescenzo, Hong, Musachio, Gee, Seidel, Green, Pike, Duman, Innis: "In vivo and in vitro measurement of brain phosphodiesterase 4 in rats after antidepressant administration." in: Synapse (New York, N.Y.), Vol. 61, Issue 2, pp. 78-86, (2007) (PubMed).

Creighton, Zhu, Alexeyev, Stevens: "Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation." in: Journal of cell science, Vol. 121, Issue Pt 1, pp. 110-9, (2007) (PubMed).

Baxendale, Fraser: "Mammalian sperm phosphodiesterases and their involvement in receptor-mediated cell signaling important for capacitation." in: Molecular reproduction and development, Vol. 71, Issue 4, pp. 495-508, (2006) (PubMed).

Dlaboga, Hajjhussein, ODonnell: "Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: comparison with rolipram." in: Brain research, Vol. 1096, Issue 1, pp. 104-12, (2006) (PubMed).

Terrin, Di Benedetto, Pertegato, Cheung, Baillie, Lynch, Elvassore, Prinz, Herberg, Houslay, Zaccolo: "PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases." in: The Journal of cell biology, Vol. 175, Issue 3, pp. 441-51, (2006) (PubMed).

Wang, Deng, Bugaj-Gaweda, Kwan, Gunwaldsen, Leonard, Xin, Hu, Unterbeck, De Vivo: "Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7." in: Cellular signalling, Vol. 15, Issue 9, pp. 883-91, (2004) (PubMed).

Target Details for PDE4D

Target: PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

Alternative Name: PDE4D (PDE4D Products)

Synonyms: ACRDYS2 antibody, DPDE3 antibody, HSPDE4D antibody, PDE43 antibody, PDE4DN2 antibody, STRK1 antibody, CMYA2 antibody, MMGL antibody, 9630011N22Rik antibody, Dpde3 antibody, 4732458A06Rik antibody, 9430063L05Rik antibody, C87016 antibody, D130016K21Rik antibody, D3Bwg1078e antibody, Usmg4 antibody, mKIAA0454 antibody, si:dkey-190g11.2 antibody, phosphodiesterase 4D antibody, phosphodiesterase 4D interacting protein antibody, phosphodiesterase 4D, cAMP specific antibody, phosphodiesterase 4D, cAMP-specific antibody, phosphodiesterase 4D interacting protein (myomegalin) antibody, PDE4D antibody, PDE4DIP antibody, pde4d antibody, Pde4dip antibody, Pde4d antibody

UniProt: Q07343

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling