PDE1A antibody (AA 1-50)

Catalog No. ABIN2747069

Product Details anti-PDE1A Antibody

Target: PDE1A (Phosphodiesterase 1A (PDE1A))

Binding Specificity: AA 1-50

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Confocal Microscopy (CM)

Purification: Affinity Purified

Immunogen: Synthetic peptide taken within amino acid region 1-50 on human PDE1A protein. Common to all PDE1A variants

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.6 μg/μL

References for anti-PDE1A antibody (ABIN2747069)

Rajagopal, Nalli, Kumar, Bhattacharya, Hu, Mahavadi, Grider, Murthy: "Cytokine-induced S-nitrosylation of soluble guanylyl cyclase and expression of phosphodiesterase 1A contribute to dysfunction of longitudinal smooth muscle relaxation." in: The Journal of pharmacology and experimental therapeutics, Vol. 352, Issue 3, pp. 509-18, (2015) (PubMed).

Kedia, Ückert, Oelke, Sonnenberg, Sohn, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human male urethra." in: Urology, Vol. 85, Issue 4, pp. 964.e1-6, (2015) (PubMed).

Uckert, Albrecht, Kuczyk, Hedlund, Oelke: "Phosphodiesterase type 1, calcitonin gene-related peptide and vasoactive intestinal polypeptide are involved in the control of human vaginal arterial vessels." in: European journal of obstetrics, gynecology, and reproductive biology, Vol. 169, Issue 2, pp. 283-6, (2014) (PubMed).

Yougbaré, Keravis, Abusnina, Decossas, Schall, Muller, Lugnier: "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." in: Biochimica et biophysica acta, Vol. 1842, Issue 7, pp. 916-26, (2014) (PubMed).

Abusnina, Keravis, Yougbaré, Bronner, Lugnier: "Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1." in: Molecular nutrition & food research, Vol. 55, Issue 11, pp. 1677-89, (2012) (PubMed).

Abusnina, Alhosin, Keravis, Muller, Fuhrmann, Bronner, Lugnier: "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." in: Cellular signalling, Vol. 23, Issue 1, pp. 152-60, (2011) (PubMed).

Genders, Bradley, Rattigan, Richards: "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." in: American journal of physiology. Endocrinology and metabolism, Vol. 301, Issue 2, pp. E342-50, (2011) (PubMed).

Ortiz-Capisano, Liao, Ortiz, Beierwaltes: "Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cells." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 297, Issue 5, pp. R1469-76, (2009) (PubMed).

Deplano, Giorgi, Maccarone, Santone, Nuccetelli, Basso, Bisti: "Gene expression and protein localization of calmodulin-dependent phosphodiesterase during ontogenesis of chick retina." in: Journal of neuroscience research, Vol. 86, Issue 5, pp. 1017-23, (2008) (PubMed).

Murray, Patel, Suda, Zhang, Thistlethwaite, Yuan, Insel: "Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 292, Issue 1, pp. L294-303, (2007) (PubMed).

Albrecht, Uckert, Oelke, Andersson, Jonas, Tröger, Hedlund: "Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human vagina: a potential forensic value?" in: Journal of forensic and legal medicine, Vol. 14, Issue 5, pp. 270-4, (2007) (PubMed).

Baxendale, Fraser: "Mammalian sperm phosphodiesterases and their involvement in receptor-mediated cell signaling important for capacitation." in: Molecular reproduction and development, Vol. 71, Issue 4, pp. 495-508, (2006) (PubMed).

Sairenji, Satoh, Sugiya: "Ca(2+)/calmodulin-dependent cyclic nucleotide phosphodiesterase in cGMP metabolism in rabbit parotid acinar cells." in: Biomedical research (Tokyo, Japan), Vol. 27, Issue 1, pp. 37-44, (2006) (PubMed).

Santone, Giorgi, Maccarone, Basso, Deplano, Bisti: "Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina." in: Journal of neuroscience research, Vol. 84, Issue 5, pp. 1020-6, (2006) (PubMed).

Whitehead, Earle, Fetter, Xu, Hartman, Chan, Zhao, Piazza, Klein-Szanto, Pamukcu, Alila, Bunn, Thompson: "Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival." in: Molecular cancer therapeutics, Vol. 2, Issue 5, pp. 479-88, (2004) (PubMed).

Target Details for PDE1A

Target: PDE1A (Phosphodiesterase 1A (PDE1A))

Alternative Name: PDE1A (PDE1A Products)

Synonyms: PDE1A antibody, CAM-PDE-1A antibody, HCAM-1 antibody, HCAM1 antibody, HSPDE1A antibody, AI987702 antibody, AW125737 antibody, 3'-RACEclone8phosphodiesterase1A antibody, 3-RACEclone8phosphodiesterase1A antibody, PDE1 antibody, phosphodiesterase 1A antibody, phosphodiesterase 1A, calmodulin-dependent antibody, PDE1A antibody, pde1a antibody, Pde1a antibody

UniProt: Q9JLL9

Pathways: Neurotrophin Signaling Pathway, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma