PDE10A antibody (AA 300-350)

Catalog No. ABIN2747045

Product Details anti-PDE10A Antibody

Target: PDE10A (phosphodiesterase 10A (PDE10A))

Binding Specificity: AA 300-350

Reactivity: Human, Rat, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE10A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Confocal Microscopy (CM)

Purification: Affinity Purified

Immunogen: Synthetic peptide taken within amino acid region 300-350 on human PDE10A2 protein common to all PDE10A variants.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.7 μg/μL

References for anti-PDE10A antibody (ABIN2747045)

Harada, Suzuki, Miura, Hasui, Kamiguchi, Ishii, Taniguchi, Kuroita, Takano, Stepanov, Halldin, Kimura: "Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A." in: Nuclear medicine and biology, Vol. 42, Issue 2, pp. 146-54, (2015) (PubMed).

Sancesario, Morrone, DAngelo, Castelli, Ferrazzoli, Sica, Martorana, Sorge, Cavaliere, Bernardi, Giorgi: "Levodopa-induced dyskinesias are associated with transient down-regulation of cAMP and cGMP in the caudate-putamen of hemiparkinsonian rats: reduced synthesis or increased catabolism?" in: Neurochemistry international, Vol. 79, pp. 44-56, (2015) (PubMed).

Mango, Bonito-Oliva, Ledonne, Nisticò, Castelli, Giorgi, Sancesario, Fisone, Berretta, Mercuri: "Phosphodiesterase 10A controls D1-mediated facilitation of GABA release from striato-nigral projections under normal and dopamine-depleted conditions." in: Neuropharmacology, Vol. 76 Pt A, pp. 127-36, (2014) (PubMed).

Heine, Sygnecka, Scherf, Berndt, Egerland, Hage, Franke: "Phosphodiesterase 2 inhibitors promote axonal outgrowth in organotypic slice co-cultures." in: Neuro-Signals, Vol. 21, Issue 3-4, pp. 197-212, (2013) (PubMed).

Giorgi, Melchiorri, Nuccetelli, DAngelo, Martorana, Sorge, Castelli, Bernardi, Sancesario: "PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: a key step in parkinsonism physiopathology." in: Neurobiology of disease, Vol. 43, Issue 1, pp. 293-303, (2011) (PubMed).

Ong, Gribble, Reimann, Lynch, Houslay, Baillie, Furman, Pyne: "The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release." in: British journal of pharmacology, Vol. 157, Issue 4, pp. 633-44, (2009) (PubMed).

Kruse, Møller, Tibaek, Gammeltoft, Olesen, Kruuse: "PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system." in: Brain research, Vol. 1281, pp. 25-34, (2009) (PubMed).

Bora, Gupta, Malik, Chachra, Sharma, Saini: "Development of a cell-based assay for screening of phosphodiesterase 10A (PDE10A) inhibitors using a stable recombinant HEK-293 cell line expressing high levels of PDE10A." in: Biotechnology and applied biochemistry, Vol. 49, Issue Pt 2, pp. 129-34, (2008) (PubMed).

Dlaboga, Hajjhussein, ODonnell: "Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat striatum." in: Neuropharmacology, Vol. 54, Issue 4, pp. 745-54, (2008) (PubMed).

Albrecht, Uckert, Oelke, Andersson, Jonas, Tröger, Hedlund: "Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human vagina: a potential forensic value?" in: Journal of forensic and legal medicine, Vol. 14, Issue 5, pp. 270-4, (2007) (PubMed).

Ückert, Oelke, Albrecht, Stief, Jonas, Hedlund: "Immunohistochemical description of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human labia minora." in: The journal of sexual medicine, Vol. 4, Issue 3, pp. 602-608, (2007) (PubMed).

Uckert, Oelke, Waldkirch, Stief, Albrecht, Tröger, Jonas, Andersson, Hedlund: "Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves." in: Urology, Vol. 65, Issue 3, pp. 604-10, (2005) (PubMed).

Target Details for PDE10A

Target: PDE10A (phosphodiesterase 10A (PDE10A))

Alternative Name: PDE10A (PDE10A Products)

Synonyms: HSPDE10A antibody, Pde10a3 antibody, phosphodiesterase 10A antibody, PDE10A antibody, Pde10a antibody

UniProt: Q9Y233

Pathways: cAMP Metabolic Process