RGS5 antibody

Catalog No. ABIN2730835

Product Details anti-RGS5 Antibody

Target: RGS5 (Regulator of G-Protein Signaling 5 (RGS5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RGS5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Characteristics: Homo sapiens regulator of G-protein signaling 5 (RGS5), transcript variant 1

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human RGS5 (NP_003608) produced in HEK293T cell.

Clone: 1C1

Isotype: IgG1

Application Details

Application Notes: WB 1:2000, IHC 1:150, FLOW 1:100

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-RGS5 antibody (ABIN2730835)

Adebiyi, Soni, John, Yang: "Lipid rafts are required for signal transduction by angiotensin II receptor type 1 in neonatal glomerular mesangial cells." in: Experimental cell research, Vol. 324, Issue 1, pp. 92-104, (2014) (PubMed).

Özen, Deierborg, Miharada, Padel, Englund, Genové, Paul: "Brain pericytes acquire a microglial phenotype after stroke." in: Acta neuropathologica, Vol. 128, Issue 3, pp. 381-96, (2014) (PubMed).

Pastò, Marchesi, Diamantini, Frasson, Curtarello, Lago, Pilotto, Parenti, Esposito, Agostini, Nitti, Amadori: "PKH26 staining defines distinct subsets of normal human colon epithelial cells at different maturation stages." in: PLoS ONE, Vol. 7, Issue 8, pp. e43379, (2012) (PubMed).

Target Details for RGS5

Target: RGS5 (Regulator of G-Protein Signaling 5 (RGS5))

Alternative Name: RGS5 (RGS5 Products)

Background: This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight: 20.8 kDa

Gene ID: 8490

NCBI Accession: NM_003617

HGNC: 8490

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling